About

• Department Affiliations:
• Biology

My Research

The lab aims to define a role for nuclear glutathione signaling in plant development and regeneration. In the Arabidopsis root tip stem cells can be manually excised, which induces fate-specified cells to reprogram back to stem cells. I showed that nuclear glutathione coordinates cell cycle behavior after root tip injury, which in turn is necessary for efficient regeneration to occur. However, the molecular basis of glutathione-based cell cycle regulation is unknown.

My work addresses how glutathione is localized to the nucleus, and what glutathione interacts with in the nucleus to regulate cell cycle behavior. The lab will use tools we developed to conduct genome-wide screening of nuclear glutathione regulators. The lab will use proteomics, next generation sequencing, and scanning mutagenesis to identify nuclear glutathione interactors controlling cell cycle progression. These approaches will yield a comprehensive model for glutathione-based cell cycle regulation during regeneration and can be generalized to study other metabolites that regulate development.