Congratulations to James Isaiah (Ike) Emerson, a graduate student and research assistant in the Conlon Lab, Pablo Ariel, Ph.D., Director, Microscopy Services Laboratory, Department of Pathology and Laboratory Medicine, Wei Shi, a postdoctoral fellow in the Conlon Lab, and Frank L. Conlon, Ph.D., Professor of Biology and Genetics, for publishing article, titled “Sex Differences in Mouse Cardiac Electrophysiology Revealed by Simultaneous Imaging of Excitation-Contraction Coupling”, in The Journal of Cardiovascular Development and Disease.
The authors developed a novel method to simultaneously measure action potentials, calcium flux, and contraction in isolated mouse cardiomyocytes. Using this method they uncovered baseline sex differences in each step of cardiac excitation-contraction coupling in male and female mice and connected these intracellular sex differences to those seen in EKG recordings. The work was featured in Volume 10, Issue 12, of The Journal of Cardiovascular Development and Disease and can be read online now.