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Joe W. and Evelyn M. Grisham Distinguished Professor Chair of Pathology and Laboratory Medicine

Research Interests

My research lab focuses on the molecular pathogenesis of endometrial cancer, the most common gynecologic cancer in the Western world.  Current projects include developing molecular diagnostics for predicting endometrial cancer histotype, stage, and recurrence developing clinical and lab-based algorithms for the identification of patients with hereditary endometrial cancer (Lynch Syndrome), discovering novel molecular mediators of endometrial cancer invasion and metastasis, and identifying novel signaling pathways important in the pathogenesis of endometrial cancer.

Selected Publications

Bartley AN, Luthra R, Saraiya DS, Urbauer DL, Broaddus RR. Identification of cancer patients with Lynch syndrome: clinically significant discordances and problems in tissue-based mismatch repair testing. Cancer Prev Res (Phila) 2012; 5(2):320-7. PMCID: PMC3273660

Djordjevic B, Hennessy BT, Li J, Barkoh BA, Luthra R, Mills GB, Broaddus RR. Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing. Mod Pathol 2012; 25(5):699-708.  PMCID: PMC3341518.

Kurnit, K.C., Kim, G., Fellman, B.M., Urbauer, D., Mills, G.B., Zhang, W., Broaddus, R.R.  CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence.  Mod Pathol 2017; 30:  1032-1041.  PMCID: PMC5493522

Bruegl AS, Djordjevic B, Batte B, Daniels MS, Fellman BM, Urbauer DL, Luthra R, Sun C, Lu K, Broaddus RR. Evaluation of clinical criteria for the identification of Lynch Syndrome among unselected endometrial cancer patients. Cancer Prev Res (Phila) 2014; 7:  686-697.  PMCID:  PMC4090057

Estrella JS, Ma LT, Milton DR, Yao JC, Wang H, Rashid A, Broaddus RR. Expression of estrogen-induced genes and estrogen receptor β in pancreatic neuroendocrine tumors: implications for targeted therapy. Pancreas 2014; 43:  996-1002.  PMCID:  PMC4628823

Bowser JL, Blackburn MR, Shipley GL, Molina JG, Dunner K, Broaddus RR. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest 2016; 126(1): 220-38. PMCID: PMC4701552

Deng L, Feng J, Broaddus RR.  The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.  Cell Death Dis 2010; e32.  PMCID:  PMC2976047

List of publications from PubMed

Trained Mentor

Russell Broaddus