Join the UNC Program for Precision Medicine in Healthcare (PPMH) for Precision Health @UNC: Pharmacogenomics and Decision Support in the EHR, a virtual mini-symposium on Wednesday October 27th from 1:00 to 3:00pm. At this interactive event, you will engage in discussion with leading Precision Medicine researchers at UNC. Presenters will explore mechanisms for predicting how a patient’s genome will influence their response to medications, implementing pharmacogenomics in the clinic, and development of EHR decision support.
Presenters:
Daniel Crona, PharmD, PhD: The ongoing quest for perfection – or at least precision – of tacrolimus dosing in bone marrow transplant
Associate Professor, Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy
This presentation focuses on attempts at UNC to develop a precision dosing model of tacrolimus for patients receiving an allogeneic stem cell transplant. Specifically, we will discuss tacrolimus pharmacogenetics and the development of a tacrolimus population pharmacokinetic model, which serve as the foundation for our precision dosing efforts. Ultimately, we believe that a tacrolimus precision dosing model will replace a “one size fits all” dosing paradigm, and will better help to prevent severe acute graft-versus-host syndrome and tacrolimus toxicities.
Klarissa Jackson, PhD: Interindividual variability in drug metabolism: Implications for precision medicine in ethnically diverse populations
Assistant Professor, Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy
This presentation will focus on recent findings regarding the influence of interindividual variation in cytochrome P450 (CYP) 3A enzyme activity on the metabolism of anti-cancer small molecule tyrosine kinase inhibitors, using lapatinib as a case study. Lapatinib undergoes metabolic activation by CYP3A4 and polymorphic CYP3A5 to form a chemically reactive metabolite, which is implicated in drug-induced liver injury. In this presentation, we will discuss the application of integrated in vitro approaches to examine interindividual differences in the metabolic activation of lapatinib. We will also discuss the implications of our findings for future translational studies to investigate how genetic and non-genetic factors affect drug metabolism and drug response in patients from understudied ethnic backgrounds.
Erin Heinzen, PharmD, PhD: The impact of recent gene discovery on treatment selection in epilepsy
Associate Professor, Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy
This presentation will discuss recent progress in epilepsy genetics and how these discoveries are being used to guide treatment approaches in patients with different types of genetic epilepsy.
This dynamic discussion forum will explore the breadth of Precision Health initiatives at UNC and facilitate connections between colleagues with similar research interests. We hope to see you there!
Event Agenda:
1:00-1:05 | Introductions |
1:05-1:30 | Daniel Crona presentation |
1:30-1:55 | Klarissa Jackson presentation |
1:55-2:20 | Erin Heinzen presentation |
2:20-2:55 | Panel discussion |
2:55-3:00 | Closing remarks |
Click here to register.
Email precisionmedicine@med.unc.edu for more information.
Click here to download the event flyer: PPMH mini-symposium poster Oct2021