About

The Laederach Lab is interested in better understanding the relationship between RNA structure and folding dynamics. We use a combination of computational and experimental approaches to study the process of RNA folding and assembly. In particular, we develop novel computational approaches to analyze and interpret chemical mapping data. Most recently, we have begun investigating the relationship between disease-associated Single Nucleotide Polymorphisms (SNPs) occurring in Human UTRs and their effect on RNA structure. In particular, we have been investigating regulatory RNA elements called “RiboSNitches,” which like bacterial Riboswitches undergo a large conformational change and regulate translation post-transcriptionally. SNPs in the RiboSNitch cause the conformational change.