Onyinye Iweala, MD, PhD

Assistant Professor

Specialty Area: Allergy & Immunology– environmental allergies (allergic rhinitis), chronic hives and swelling (urticaria and angioedema), food allergies including alpha-gal allergy, anaphylaxis.

Chronology: AB Magna Cum Laude: Harvard University, 2002. PhD: Harvard University Graduate School of Arts and Sciences, 2009. MD: Harvard Medical School, 2010. Internal Medicine Residency: Massachusetts General Hospital, 2010-2013. Hospitalist: Duke Regional Hospital, 2013. Attending Physician, Hospital Medicine: Durham VA Medical Center, 2014-2015. Medical Instructor: Duke Division of General Medicine, Department of Medicine, 2014-2015. Allergy & Immunology Clinical Fellowship: University of North Carolina at Chapel Hill, 2015-2017. Postdoctoral Research Fellowship in Allergy & Immunology: UNC Food Allergy Initiative and Thurston Arthritis Research Center, 2017-2018. Clinical Instructor in Pediatrics: University of North Carolina, 2017-2018. Assistant Professor of Medicine: University of North Carolina, 2018-present.

Description of research and/or clinical interests: Dr. Iweala’s primary research interests include 1) the mechanisms of pathogenesis behind alpha-gal mammalian meat (red meat) allergy and 2) the regulation of IgE antibody responses. Dr. Iweala also enjoys caring for individuals with allergic conditions and/or immune dysfunction at the UNC Allergy Clinic. She has a particular interest in patients with alpha-gal allergy, chronic urticaria, and mast cell disorders.

Selected Bibliography:

Hamad A*, Iweala OI*, Henderson C, Madan S, Stouffer GA III, Commins SP, Kim EH. Recurrent Anaphylaxis During Cardiac Catheterization Due to Ethylene Oxide. The Journal of Allergy and Clinical Immunology: In Practice (2018). DOI: 10.1016/j.jaip.2018.04.017. PMID: 29715563

Iweala OI, Choudhary SK, Commins SP. Food Allergy. Current Gastroenterology Reports. 2018; 20:17. https://doi.org/10.1007/s11894-018-0624-y. PMID: 29623490

Iweala OI, Copenhaver CC, Wu EY, Moran TP. Hydroxychloroquine as a Steroid-Sparing Agent in an Infant with Chronic Urticaria. Ann Allergy Asthma Immunol. 2017 Nov 17. pii: S1081-1206(17)31174-2. doi:10.1016/j.anai.2017.10.011.

Loverde D*, Iweala OI*, Eglini A, and Krishnaswamy G. Contemporary Reviews in Critical Care Medicine: Anaphylaxis. CHEST. 2017 Aug 8. pii: S0012-3962 (17) 31332-6. doi: 10.1016/j.chest.2017.07.033.

Iweala OI and Burks AW. Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment. Curr Allergy Asthma Rep. 2016 May;16(5):37.

Iweala OI*, Smith DW*, Matharu KS, Sada-Ovalle I, Nguyen DD, Dekruyff RH, Umetsu DT, Behar SM, Nagler CR. Vaccine-Induced Antibody Isotypes Are Skewed by Impaired CD4 T Cell and Invariant NKT Cell Effector Responses in MyD88-Deficient Mice. Journal of Immunology. 2009; 183: 2252-2260.

Matharu KS, Mizoguchi E, Alonso C, Nguyen D, Mingle B, Iweala OI, McBee ME, Stefka A, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker H-C, Mizoguchi A, Nagler CR. TLR4 mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10 deficient mice. Gastroenterology. 2009; 137(4):1380-90.e1-3.

Urban JF, Steenhard NR, Solano-Aguilar GI, Dawson HD, Iweala OI, Nagler CR, Noland GS, Kumar N, Anthony RM, Shea-Donohue T, Weinstock J, Gause WC. Infection with parasitic nematodes confounds vaccination efficacy. Veterinary Parasitology. 2007; 148: 14-20.

Iweala OI and Nagler CR. Immune Privilege in the Gut: The Establishment and Maintenance of Nonresponsiveness to Dietary Antigens and Commensal Flora. Immunological Reviews. 2006; 213: 82-100.

Iweala OI. HIV diagnostic tests: an overview. Contraception. 2004 Aug; 70(2):141-7.

*These authors contributed equally to this work.

Publication list: https://www.ncbi.nlm.nih.gov/pubmed?term=Iweala%20OI%5BAuthor%5D&cmd=DetailsSearch