European American Project CRASH

Project CRASH is a prospective cohort study examining genotypic and phenotypic characteristics associated with the recovery process after motor vehicle collision. Patients experiencing motor vehicle collision are enrolled in the study at emergency department study sites in Michigan, Massachusetts, New York, and Florida. Study participants complete a baseline assessment in the ED as well as a follow-up interview 6 weeks, 6 months, and 1 year following the motor vehicle collision. This study is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056328). Dr. McLean is PI of this study.

Status: in progress

Study Sites and Networks

Project Crash Sites

 

Publications, Abstracts and Presentations


Related Publications

  1. Platts-Mills TF, Hunold K, Ballina L, Bortsov AV, Peak DA, Jones JS, Swor RA, Lee DC, Domeier RM, Hendry PL, Rathlev NK, McLean SA.  More Educated Emergency Department Patients are Less Likely to Receive Opioids for Acute Pain.  Pain 153(5):941-2, 2012.
  2. McLean SA. The Potential Contribution of Stress System Responses to the Transition to Chronic Whiplash-Associated Disorders.  Spine 36:S226-32, 2011.
  3. Platts-Mills TF, Ballina L, Bortsov AV, Soward A, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, Hendry PL, McLean SA. Using Emergency Department-Based Inception Cohorts to Determine Genetic Characteristics Associated with Long Term Patient Outcomes: Methodology of the CRASH Study. BMC Emergency Medicine 2011.
  4. Sterling M, McLean SA, Sullivan MJ, Elliott J, Butenhuis J, Kamper SJ.  Potential processes involved in the initiation and maintenance of Whiplash Associated Disorders (WAD).  Spine 36:S322-9, 2011.
  5. Lee YM, Platts-Mills TF, MacWilliams J, Jones JS, Domeier RM, Swor RA, Sochor MA, Schneider J, McLean SA. Description of Motor Vehicle Collisions by Participants in Emergency Department-Based Studies: Are they Accurate?  West J Emerg Med. 2011 (in press).
  6. McLean SA, Diatchenko L, Lee YM, Swor RA, Domeier RM, Jones JS, Jones CW, Reed C, Harris RE, Maixner W, Clauw DJ, Liberzon I.  Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after minor motor vehicle collision.  Journal of Pain 12(1):101-7, 2011.
  7. Lee DC, McLean S, Barton E, Hahn SJ. Variations in local institutional Review Boards (IRB) responses to a standard, multi-center, emergency department-based genetic research project. Academic Emergency Medicine. 2010:17(5):S(1)S140-141.


Related Abstracts

  1. Qadri YJ, Bortsov AV, Swor RA, Peak DA, Jones JS, Rathlev NK, Lee DC, Domeier RM, Hendry PL, Mclean SA. Genetic polymorphisms in the Dopamine Receptor D2 are associated with acute pain severity after motor vehicle collision.  Accepted to the 2012 Annual Meeting of the American Society of Anesthesiologists. **Selected for oral presentation in the 2012 ASA "Best Abstracts" session.
  2. Goetzinger A, Orrey D, Lee Y, Platts-Mills T, Bortsov, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, Liberzon I, McLean S.  Persistent Neck Pain is Associated with Increased Risk of significant PTSD and Depressive Symptoms and Greater Health Service Utilization 6 Weeks after Motor Vehicle Collision.  Accepted for poster presentation at the International Association of the Study of Pain's Bi-Annual World Congress on Pain, Milan, Italy, August 2012.
  3. Smith JE, Ulirsch J, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, Diatchenko, McLean S.  FKBP5 Variants Predict Neck Pain Persistence Six Weeks After Motor Vehicle Collision.  Accepted for poster presentation at the International Association of the Study of Pain's Bi-Annual World Congress on Pain, Milan, Italy, August 2012. Selected for oral presentation at the 2012 Annual Meeting of the American Society of Anesthesiologists.
  4. Lewis GC, Platts-Mills TF, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domeier R, Hendry P, McLean SA. Incidence and predictors of psychological distress after motor vehicle collision. Presented at the Society for Academic Emergency Medicine Annual Conference, Chicago, IL 2012. **Selected for oral presentation in special "Future Stars of Emergency Medicine" session.
  5. Ballina L, Diatchenko L, Ulirsch J, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Sexually Dimorphic Influence of COMT on Distress in the Immediate Aftermath of Trauma. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  6. Bortsov A, Soward A, Diatchenko L, Ulirsch J, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Tryptophan Hydroxylase 2 Synonymous Polymorphism rs7305115 is Associated with Acute Psychological Response after Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  7. Smith J, Bortsov A, Ulirsch J, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA.  FKBP5 Polymorphism Predicts Peritraumatic Dissociation after Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012  **Scored in the top 1% of all abstracts submitted to conference and received a Top Poster Finalist award.
  8. Ulirsch J, Bortsov A, Smith J, Diatchenko L, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. ADRA2A Variants Predict Peritraumatic Dissociation After Motor Vehicle Collision. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012
  9. Goetzinger A, Orrey D, Lee Y, Platts-Mills T, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Peritraumatic Psychological Distress and Mild Traumatic Brain Injury Symptoms (MTBI) are Associated in the Early Aftermath of Trauma. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012. ** Scored in the top 1% of all abstracts submitted to conference and received a Top Poster Finalist award.
  10. Platts-Mills T, Ballina L, Diatchenko L, Bortsov A, Swor R, Peak D, Jones J, Rathlev N, Lee D, Domieir R, Hendry P, Liberzon I, McLean SA. Influence of COMT HPS Haplotype on Peritraumatic Distress Severity among Women Experiencing Motor Vehicle Collision: Report of an Age x Gene Interaction.  Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012.
  11. Xie H, Tamburrino M, Dennis M, Elhai J, Brickman K, Liberzon I, McLean S, Wall J, Bauer W, Wang X.  Relationships Between Brain Structural Properties and Acute Pain and Stress After a Motor Vehicle Accident. Presented at the Annual Meeting of the Society for Neuroscience, Washington, DC, 2011.
  12. Whittington K, Bortsov A, Soward AC, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Hendry P, Maixner W, Slade G, McLean SA. A pain in the neck? Which regions of body pain are most associated with pain interference and other health outcomes 6 weeks after motor vehicle collision. Presented at the Annual Meeting of the APS, Austin, TX, 2011, and the Annual Meeting of the Society of Academic Emergency Medicine, Boston, MA, 2011.
  13. Bortsov A, Whittington K, Lee Y, Soward AC, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, McLean SA Individual vulnerability factors, but not collision-related factors, are associated with extent of moderate or severe pain symptoms in the immediate aftermath of motor vehicle collision. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  14. Lee Y, Orrey D, Bortsov A, Whittington K, Jones J, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Maixner W, Slade G, Fillingim R, McLean SA. Shared Vulnerability to pain and post-concussive syndrome in the early aftermath of motor vehicle collision. Presented for Presentation at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  15. Edwards L, Mitchell P, Jones J, Hendry P, Peak D, Swor R, Lee D, Rathlev N, Domeier R, Bortsov A, Platts-Mills T, Fillingim R, McLean SA. Increased catastrophizing and reduced recovery expectations in the early aftermath of motor vehicle collision among African Americans vs. European Americans. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  16. Ballina L, Platts-Mills T, Jones J, Peak D, Swor R, Soward AC, Whittington K, Lee D, Rathlev N, Domeier R, Orrey D, Liberzon I, McLean SA. Receipt of mental health care services in the initial weeks after motor vehicle collision is rare among patients with persistent neck pain and substantial co-morbid PTSD symptoms. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  17. Halawa OI, Mclean SA, Lee YM, Platts-mills TF, Zaleski E, Withrow A, Clauw DJ, Liberzon I. Elevated Cortisol Levels after Motor Vehicle Collision Predict Post Traumatic Stress Disorder and Depressive Symptoms at 1 Month. Presented at the annual meeting of the Society for Biological Psychiatry, New Orleans, LA, 2010.
  18. Roane BM, Orrey D, Soward AC, Swor RA, Liberzon I, Clauw DJ, McLean SA. Pain and psychological symptom differences in African Americans and European Americans experiencing motor vehicle collision. Presented at the annual meeting of the American Pain Society, Baltimore, MD, 2010.
  19. Swor RA, Lee YM, McLean SA. Spinal board immobilization may be associated with persistent pain after Motor Vehicle Crash. National Association of EMS Physicians, Phoenix, AZ 2010.

Photos

 

Crash Meeting

European American CRASH Annual Meeting

 

APS Austin 2011

Abbey Whittington MS, Phyllis Hendry MD, and Andrey Bortsov in front of Abbey's poster at American Pain Society 2011, Austin, TX