Welcome to Xian Chen’s laboratory at the University of North Carolina at Chapel Hill. We are part of the Department of Biochemistry and Biophysics at UNC Chapel Hill School of Medicine, and Lineberger NCI Comprehensive Cancer Center. Dr. Chen is also the Faculty Director for Quantitative Proteomics Center for Disease Markers and a member of Lineberger NCI Comprehensive Cancer Center and Programs in Molecular Biology and Biotechnology.
Without the need of pre-convinced notion or hypothesis, emerging systems biology approaches, proteomics in particular, provide unique opportunity to resolve the complexity of the operation of biological systems including those phenotype-specific changes in protein expression, post-translational modifications, and protein-protein interactions. Our research group has been focusing on developing and applying cutting-edge technologies of proteomics to investigate systematically the molecular pathways/mechanisms of real-time pathogenesis of various human diseases such as immune disorders, inflammation-associated cancers, etc. In general our systems investigation is discovery-driven and can generate multiple biological hypothesis which allows for the dissection of dynamic functional networks involving multiple proteins and their temporal changes in expression and modifications. To achieve these goals with different biological systems we take full advantages of the unique strength of state-of-art mass spectrometry at the Proteomics Pathways Discovery Core for the upstream non-biased screening for the target discovery which is followed by biological characterization using a variety of molecular/cellular biology approaches.