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UNC named NIH Autism Center of Excellence for third time
As part of a five-year, $7.5 million award, UNC researchers led by Joseph Piven, MD, will follow up on innovative imaging studies to create interventions to help children with autism. Sep 19, 2017
NIH grant to help UNC researchers explore microRNA as route to Alzheimer’s therapy
The National Institute on Aging awarded a $2.6-million, five-year grant to UNC’s Mohanish Deshmukh’s lab to explore miR-29, a key molecule that helps mature brain cells avoid death. Sep 14, 2017
Unraveling Alzheimer’s: New Study Documents How Brain Cells Go Bad
In a first-of-its-kind study, UNC researchers show how a damaging cascade of events inside brain cells – and related to Alzheimer’s disease – can be stopped or reversed. Sep 07, 2017
Gupton Lab Featured on Cover of Molecular Biology of the Cell
The axon guidance cue netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. In this study, we detail a novel molecular mechanism by which the brain-enriched E3 ubiquitin ligase TRIM9 orchestrates multimerization of DCC, requisite activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, all during netrin-dependent neuronal morphogenesis. We are the first to show that non-degradative ubiquitination of a receptor alters kinase activation and signaling pathways during morphogenesis. Sep 01, 2017
Patricia Maness, PhD, Receives NIH R01 Titled, "Mechanisms of Developmental Spine Pruning Regulated by Ig-CAMS and Semaphorins"
The focus of this grant is to illuminate a novel mechanism for dendritic spine pruning in the mammalian neocortex by immunoglobulin (Ig)-class cell adhesion molecules and secreted Semaphorins. The overall goal is to identify mechanisms that govern synaptic connectivity in the mammalian neocortex, and to elucidate how their deficiency contributes to abnormal brain wiring relevant to neurodevelopmental disorders. Aug 31, 2017
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