About

David Margolis – Associate Director is the Sarah Graham Kenan Distinguished Professor of Medicine. He is the Director of the UNC HIV Cure Center created to support novel and impactful research needed to advance towards therapies to induce an HIV remission. He has conducted seminal translational HIV research: investigating basic molecular, virological, and immunological phenomenon, and leveraging insights to develop new interventions in HIV disease. Directing the Dallas VAMC ID division and AIDS Clinical Trials Unit before coming to UNC, for more than 25 years the central focus of his research has been the study of molecular mechanisms of HIV proviral latency and persistence despite potent antiretroviral therapy (ART). He is the principal investigator for CARE (Collaboratory of AIDS Researchers for Eradication), an NIH-funded research organization that seeks to develop the tools to bring an HIV cure from the bench to the clinic. His clinical research group has developed the concept of HIV latency reversing agents, testing drug that may force HIV out of hiding in numerous clinical trials. Recently studies have combined immunotherapies (vaccines, antibodies or antibody-like molecules, or antiviral cellular therapy) and small-molecule anti-latency agents (HDAC inhibitors), seeking to deplete persistent HIV infection. He has been elected as a fellow of the American College of Physicians, the Infectious Diseases Society of America, and the American Association for the Advancement of Science.