| University of North Carolina at Chapel Hill
Division of Infectious Diseases, Department of Medicine
Dr. Bartelt’s primary research focuses on understanding the immunological consequences and microbial-mediated pathogenesis of environmental enteropathy—a condition of enteric dysfunction underlying childhood malnutrition. His lab uses murine malnutrition models and gnotobiotic techniques to unravel mechanisms of poorly understood, but highly prevalent and consequential, enteric protozoan parasites—specifically Giardia and Cryptosporidium. He is currently funded by the NIH to study how specific nutrient deficiencies and diet-dependent alterations in intestinal microbiota interact with Giardia to alter mucosal host defenses and intestinal epithelial cell restitution. The goal of this work is to develop gut restorative therapies that remediate maladaptive microbial-host interactions during malnutrition.