Chen, Xiaoxin (Luke)
| North Carolina Central University
Julius L. Chambers Biomedical/Biotechnology Research Institute
Cancer Research Program
Dr. Chen’s research interests are molecular mechanism of intestinal metaplasia in the esophagus (Barrett’s esophagus) and chemoprevention of esophageal adenocarcinoma: The goal of this project is to study the roles of gastroesophageal refluxate (acid and bile acids), genetic and epigenetic pathways in the development of Barrett’s esophagus, the premalignant lesion of esophageal adenocarcinoma, in cell culture, animal models, and humans.
Molecular mechanism and chemoprevention of alcohol and tobacco-associated oral cancer: Dr. Chen’s team focuses on aberrant arachidonic acid metabolism (especially the 5-lipoxygenase pathway) and oxidative damage in oral carcinogenesis of carcinogen-induced models in hamsters and mice. Both pharmacological (pharmaceutical and dietary agents) and genetic approaches are employed to elucidate the mechanism of oral carcinogenesis and design mechanism-based chemopreventive strategies.