Research Summary
Dr. Gulati is a physician-scientist specializing in the management of children with inflammatory bowel diseases (IBD). As such, he has a strong motivation to identify safer and more efficacious approaches to treat these patients. The goal of his research program is to understand interactions between the resident microbiota of the gut and the host epithelium in the context of chronic intestinal inflammation found in IBD. His lab is particularly interested in understanding the regulatory impact of the microbiota on Paneth cells and intestinal stem cells, which have been implicated in IBD pathogenesis. Through this mechanistic understanding, they hope to develop strategies that mitigate chronic inflammation and associated cancer-risk by enhancing epithelial function, as opposed to suppressing the immune system.
CGIBD Focus Area(s): Microbiome
Pilot and Feasibility Award 2008
Collaborators: Barnes, Bartelt, Brenner, Carroll, Fodor, Furey, Kappelman, Herfarth, Long, Redinbo, Sartor, Sheikh, Steinbach, Theriot
