Research Summary
Dr. Barnes is a gastroenterologist and clinical investigator. His research concerns clinical outcomes among patients with Inflammatory Bowel Disease (IBD). He has utilized multiple different data sources and study designs to evaluate outcomes in patients with Crohn’s disease and ulcerative colitis. He has focused on the treatment of patients after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), including the early identification of patients at risk for long-term adverse outcomes such as chronic inflammatory conditions of the pouch. He has developed multicenter cohorts to study the use of novel biologic therapies in patients with inflammatory conditions after restorative proctocolectomy with IPAA and designed a multicenter prospective pouch-related registry known as the PROP-RD Study: A Prospective Registry for the Study of Outcomes and Predictors in Pouchitis and Pouch-Related Disorders, initially funded by the Crohn’s & Colitis Foundation’s Clinical Research Alliance. The CGIBD Clinical Research Core provided data management services for PROP-RD.
The Center for Gastrointestinal Biology and Disease has featured heavily in his research, initially awarding a Pilot and Feasibility Grant, and then offering the data management, biostatistics, and microbiome core expertise and consultation to carry out these ongoing studies.
CGIBD Focus Area(s): Clinical/Translational Research
Pilot and Feasibility Award 2017
Collaborators: Barritt, Brenner, Dellon, Evon, Furey, Gulati, Herfarth, Kappelman, Long, Moon, Peery, Sandler, Sartor, Steinbach, Shaheen Sheikh
