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Assistant Professor, Dept. of Microbiology & Immunology

Research Summary

Dr. Arthur’s primary research interest is understanding specific mechanisms by which inflammation-associated alterations to the gut microbiota influence neoplasia and tissue remodeling. Her laboratory investigates how the functional capabilities and molecular features of resident microbes impact mucosal colonization, inflammatory bowel diseases (IBD), and inflammation-associated pathologies including fibrosis and tumorigenesis. Her lab performs basic and translational research combining microbiology, immunology, genomics, bioinformatics, and gnotobiotic mouse models to identify inflammatory, pro-carcinogenic, and pro-fibrotic resident intestinal bacteria and define mechanisms by which these bacteria promote disease. The goal of this research is to define functional capabilities, microbial genes and pathways that are causally and mechanistically linked to human gastrointestinal disease. These studies will contribute essential knowledge required for the development of therapeutic tools to manipulate the intestinal microbiota and alleviate human digestive disease.

CGIBD Focus Area(s):  Microbiome

Pilot and Feasibility Award 2013

Collaborators:  Carroll, Fodor, Furey, Sartor, Sheikh, Steinbach, Ting, Wang