Research Summary
Dr Burclaff is an epithelial stem cell biologist with training in the stomach and intestine under the mentorship of Drs Jason Mills at Washington University in St Louis and Scott Magness at UNC. His interests involve better understanding what regulates stem cell activity in homeostasis and in diseased or injured organs. The Burclaff Group uses genetically modified cultures of primary human intestinal stem cells on engineered platforms to study regulators of cell cycle, stemness, and metabolic activity. A major goal of this work is to define novel transcriptional regulators of stem cell activity and how changes in these networks may predispose for or worsen prognosis of diseases such as inflammatory bowel disease. This work has been supported with grants from the NIH NIDDK, the AGA, and a Pilot & Feasibility Award from the CGIBD.
Pilot and Feasibility Award 2022
Collaborators: Magness, Bhatt, Williamson
