The Garman Lab is predominantly focused on esophageal injury and repair, specifically the role of esophageal submucosal glands in the formation of premalignant esophageal disease. In order to perform this research, she partnered with veterinary colleagues at NCSU through the CGIBD-funded Large Animal Models Core. Earlier in her career she was mentored on a K08 award by CGIBD-member Susan Henning. She was able to obtain preliminary data with support from a CGIBD pilot/feasibility award. She was recently awarded an R01 to study the role of gastrin in acinar ductal metaplasia in the esophagus that relies on the use of CGIBD Large Animal Models Core. She has also received a pilot from Duke CTSI to study an esophageal stem cells using an auto-transplantation model. This pilot project involves harvesting porcine esophageal stem cells during endoscopy using the CGIBD Large Animal Models Core, expanding them in culture and then auto-transplanting the cells into areas of esophageal injury. A newer area of research for her group is the role of microbes in esophageal and gastric health and intestinal stem cell survival in the context of transplantation.
Relevance of Research to CGIBD Mission: Dr. Garman’s research is focused on esophageal injury and repair, particularly the role of esophageal submucosal glands. The research would be impossible without the CGIBD Large Animal Models Core. She collaborates with other CGIBD members to conduct her research.
CGIBD Focus Area(s): Regenerative Medicine/Repair; Clinical/Translational Research
Pilot Feasibility Award 2013
Collaborators: Blikslager, Gonzalez