A major emphasis area of the Caron laboratory is to explore the normal and pathological functions of G protein-coupled receptors (GPCRs) in lymphatic vessels of the gastrointestinal tract. Lymphatics play essential roles in maintaining appropriate interstitial fluid balance, trafficking of immune cells and absorption of fat with the gastrointestinal tract. Using state-of-the-art biochemical, proteomic, genomic and animal model approaches our studies will expand the repertoire of GPCR pathways that play important functions in the regulation of the neurolymphocrine unit within the GI tract, and potentially uncover unique and pharmacologically-tractable pathways for the improvement of digestive health.
Relevance of Research to CGIBD Mission: Research in the Caron Lab seeks to understand how lymphatic vessels contribute to normal and disease physiology of the gastrointestinal tract. Our focus on vascular biology brings integrative physiology and interdisciplinary insights to the overall mission of the CGIBD.
CGIBD Focus Area(s): Regenerative Medicine/Repair