Research Summary
Dr. Bartelt is a physician-scientist with board certification in Clinical Infectious Diseases and Tropical Medicine. Research in his laboratory is focused on determinants of pathogen colonization (dietary, microbiota-dependent, host-dependent) and ways disrupted intestinal microbial communities can perpetuate mucosal dysfunction during chronic pathogen colonization. He collaborates extensively with other members of the CGIBD and heavily utilized the Gnotobiotic Core to establish the first prolonged intestinal mono-association with a eukaryotic organism, Giardia lamblia (Giardia). He is using this model to determine specific intestinal bacterial contributors to Giardia-induced gut dysfunction and growth impairment—a major global health problem in undernourished children. This work also leverages technologies available in the Advanced Analytics Core. New directions include expanding studies of microbiota-pathogen interactions to the emerging global threat of multi-drug resistant Enterobacterales intestinal colonization.
CGIBD Focus Area(s): Microbiome
Pilot and Feasibility Award 2015
Collaborators: Andermann, Carroll, Fodor, Gulati, Peery, Sandler, Sartor, Ting
