Functional gastrointestinal (GI) diseases are the most common diagnoses in gastroenterology. Such disorders, like irritable bowel syndrome or functional dyspepsia, are recognized by altered GI sensitivity and motility. Though the pathophysiology is complex, a conserved feature is the bidirectional alteration in brain- gut signaling. Thus, these are classified as disorders of brain-gut interaction. While the vagus nerve is the main brain-gut link, how the brain communicates via that vagus nerve to modulate GI epithelial sensory function is unknown. The Kaelberer laboratory seeks to delineate the gut-to-brain and brain-to-gut neural circuitry that forms the basis of our gut sense. The vision is to understand the implications of our gut sense in how we navigate our food landscape.
Relevance of Research to CGIBD Mission: Dr. Kaelberer’s research lies at the intersection of multiple disciplines and incorporated all aspects of gastrointestinal biology and disease. This relies on the collaborative community of CGIBD members.
CGIBD Focus Area(s): Clinical/Translational Research
Collaborators: Diego Bohorquez, Rodger Liddle, Scott Magness