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Professor, Dept. of Pediatrics, Division of Pediatric Gastroenterology

Research Summary

Dr. Kappelman is Professor of Pediatrics and Adjunct Professor of Epidemiology. His clinical specialty is pediatric gastroenterology, with a focus on children and young adults with inflammatory bowel disease (IBD). He conducts studies of disease epidemiology, cost, natural history, patient reported outcomes, and comparativeness effectiveness research (CER) in IBD as well as the translation of evidence into practice. Another focus of his research is patient engagement, and he has experience engaging disease-focused communities through his work with the Patient-Centered Outcomes Research Institute Patient-Powered Research Networks. He co-directs the Community and Stakeholder Engagement and the Research Recruitment and Retention programs in the NC Translational and Clinical Sciences Institute (TraCS), UNC’s Clinical and Translational Science Award (CTSA). He has experience in both observational and interventional study designs. He currently serves as the PI for a large PCORI-funded observational CER study of adult IBD, is Co-PI of a CDC U01 award evaluating racial and ethnic differences in the epidemiology, treatment, and outcomes in children and adults with IBD, and co-PI of a second CDC U01 to evaluate the role of social determinates of health in patients with IBD and test the effectiveness of a text-based messaging system to improve patient activation and decrease health disparities. He previously led a large pragmatic clinical trial to compare anti-TNF monotherapy and combination therapy in pediatric Crohn’s disease.

CGIBD Focus Area(s):  Clinical/Translational Research

Pilot and Feasibility Award 2007

Collaborators:  Barnes, Barritt, Brenner, Evon, Gulati, Herfarth, Long, Moon, Sandler