Research Summary
Dr. Good’s basic science and translational laboratory studies the cellular and molecular mechanisms underlying the pathogenesis of necrotizing enterocolitis (NEC), a severe intestinal disease and a significant complication of prematurity. For 14 years, her research has been devoted to understanding the signaling pathways regulating intestinal injury during NEC and how these can be attenuated through targeted therapies. Her published research includes more than 100 publications related to prematurity, intestinal development, and NEC. The research program is motivated by a determination to improve outcomes for preterm neonates. This focus has led to the design and implementation of clinically relevant techniques including neonatal human enteroid culture, NEC-on-a-chip microfluidics technology, multi-parametric flow cytometry on intestinal immune cells, and epithelial and stem cell characterization in the neonatal intestine. To further facilitate innovative research and collaboration between investigators studying NEC, she developed and directs a multi-institutional NEC Biorepository that houses tens of thousands of samples from neonates with and without NEC. Transformative clinical/translational research studies optimize the acquisition of data from these samples.
CGIBD Focus Area(s): Regeneration and Repair
Collaborators: Magness
