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Contact Information

8015 Burnett-Womack, CB 7584
University of North Carolina
Chapel Hill NC 27599-7584
(O) 919 966-2516

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Dept. of Medicine, Division of Gastroenterology and Hepatology
Director, UNC Liver Center
University of North Carolina at Chapel Hill

Research Summary

Michael Fried is a hepatologist who has performed translational and clinical studies related to viral hepatitis. He has served as the principal investigator or co-investigator on numerous phase I through phase III clinical trials that have contributed greatly to defining the treatment of chronic viral hepatitis and to characterizing direct-acting antiviral agents, which are the newest generation of therapeutics for hepatitis C. He served as Chair or co-Chair of three NIH-sponsored clinical research networks in viral hepatitis. He is currently the co-Chair of the NIH NIDDK Hepatitis B Research Network, which is performing clinical and laboratory studies of patients in different phases of hepatitis B infection.  More recently, he has served as co-PI with Dr. David Nelson at University of Florida, of an international multicenter longitudinal, observational study of patients being treated for HCV at academic and community medical centers in order to understand the true real world safety and effectiveness of new treatment regimens for hepatitis C (HCV-TARGET).  He has been awarded two PCORI grants (Fried, co-PI) to evaluate patient reported outcomes with HCV therapy, using the HCV-TARGET infrastructure.  He received the Food and Drug Administration’s Award for Regulatory Science Excellence for HCV-TARGET.

Relevance of Research to CGIBD Mission:  The research conducted by Michael Fried on chronic hepatitis is highly relevant to the mission of the CGIBD to lower the burden of suffering from GI and liver disease. His research has created opportunities for interested students, fellows, and junior faculty to participate in clinical and translational research as part of Team Science or on niche projects, they can develop and lead.

CGIBD Focus Area(s):  Clinical/Translational Research

Collaborators:  Evon, Galanko, Lemon