Edward Miao, MD, PhD
Dept. of Microbiology & Immunology
School of Medicine
University of North Carolina at Chapel Hill
Edward Miao studies the mechanisms by which the innate immune system distinguishes pathogens from those microorganisms that do not encode virulence factors. Pathogens often attempt to manipulate the cytosolic compartment; the simplest examples are toxins, examples that are more complex include type III secretion systems, and the ultimate interaction with the host cytosol is cytosolic invasion. Cytosolic contamination or perturbation is detected by inflammasomes that activate caspase-1, or by caspase-11. His laboratory studies a variety of bacterial pathogens, including Salmonella, Listeria, Burkholderia, Chromobacterium, Pseudomonas, and Legionella. His laboratory has studied immunopathology as well, developing new models of endotoxic shock and studying colitis models. The lab is also now studying the natural killer cell and cytotoxic T cell response to infection with a focus on the mechanisms of apoptosis that are induced by NK/CTL attack
Relevance of Research to CGIBD Mission: The focus of Dr. Miao’s research is to understand how the innate immune system distinguishes pathogens from non-pathogenic bacteria. His research includes colitis models. He is a former pilot/feasibility recipient who collaborates with several CGIBD members.
CGIBD Focus Area(s): Microbiome
Collaborators: Carroll, Fodor, Hansen, Sartor, Ting