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Yeh, Jen Jen

Contact Information

Office Location: LCCC 22-021

Mailing Address:
CB# 7213
1150 Physicians Office Building
101 Manning Drive
Chapel Hill, NC 27599-7213
Office Phone: 919 966-5221
Lab Phone: 919 966-6673

Website Links

Yeh Lab


Dept. of Surgery, Division of Surgical Oncology
Dept. of Pharmacology
School of Medicine
University of North Carolina at Chapel Hill

Research Summary

Jen Jen Yeh is a surgical oncologist. The goal of her laboratory is to identify novel therapeutic targets in pancreatic cancer using a combination of bioinformatics, molecular and translational approaches including patient-derived tissues and innovative mouse model studies. She has identified and validated prognostic molecular signatures for patients with localized pancreatic cancer. More recently, her group has expanded computational approaches to focus on deconvoluting the complexity of different tissue compartments that influence genomic analyses of patient samples. She has identified two distinct tumor subtypes in patients associated with patient outcome. Both subtypes exhibit differences in their kinase activation profiles. The next step will be to evaluate subtypes in relation to treatment response in both preclinical and clinical trials.

Relevance of Research to CGIBD Mission:  Jen Jen Yeh is a surgical oncologist with a research focus on pancreatic cancer. She and members of her lab have taken advantage of various enrichment activities of the CGIBD.

CGIBD Focus Area(s):         Clinical/Translational Research 

Collaborators:                      Allbritton, Azcarate, Keku