Cryo-EM Core Facility Determines High-Resolution Structure of Key DNA-sensing Protein
September 11, 2020
Led by Qi Zhang, PhD, and Robert McGinty, MD, PhD, UNC-Chapel Hill scientists used cryo-electron microscopy technology to produce the first-ever high-resolution structure of the protein cGAS bound to the DNA packaging unit inside human cell nuclei, revealing how cGAS responds to foreign or damaged DNA, but not the body’s...