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  1. Wan J, Tanratana P, Roest M, Gruber Am Pawlinski R, Wolberg AS, Mackman N, Grover SP. A novel mouse whole blood thrombin generation assay sensitive to FXI- and FIX-mediated amplification of coagulation. Blood Adv. In press.
  2. Kawano T, Hisada Y, Grover SP, Schug WJ, Paul DS, Bergmeier W, Mackman N. Decreased platelet reactivity and function in a mouse model of human pancreatic cancer. Thromb Haemost In Press. 2022.
  3. Grover SP, Bharathi V, Posma J, Griffin J, Palumbo J, Mackman N, Antoniak S. Thrombin mediated activation of PAR1 enhances doxorubicin induced cardiac injury in mice. Blood Adv In Press. 2022. PMID: 36477178.
  4. Grover SP, Sundler Bjorkman L, Egesten A, Moll S, Mackman N. Hereditary angioedema is associated with an increased risk of venous thromboembolism. J Thromb Haemost 20(11):2703-2706, 2022. PMID: 36053174.
  5. Nayak L, Sweet DR, Thomas A, Lapping SD, Kalikasingh K, Madera A, Vinayachandran V, Padmanabhan R, Vasudevan NT, Myers JT, Huang AY, Schmaier A, Mackman N, Liao X, Maiseyeu A, Janin MK. A targetable pathway in neutrophils mitigates both arterial and venous thrombosis. Sci Transl Med In press, 2022. PMID: 36044595.
  6. Smith P, Rosell A, Farm M, Bruzelius M, Aguilera Gatica K, Mackman N, Oleberg J, Thalin, C. Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: a feasibility study based on two VTE cohorts. PloS One 17(7):e0270865, 2022 PMID: 35901107.
  7. Mwiza JMN, Lee RH, Paul DS, Holle LA, Cooley BC, Nieswandt N, Schug WJ, Kawano T, Mackman N, Wolberg AS, Bergmeier W. Both G protein-coupled and immunoreceptor tyrosine-based motif receptors mediate venous thrombosis in mice. Blood 139(15):2269-2271, 2022. PMID: 35358299.
  8. Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsure M, Lacroix R, Kim SK, Mackman N, Mayr M, Menasche P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witner K, Sluuijter JPG. Methods for the identification and characterization of extracellular vesicles in cardiovascular studies- from exosome to microvesicles. Cardiovasc Res, In press. PMID: 35325061.
  9. Archibald S, Hisada Y, Bae-Jump VL, Mackman N. Evaluation of a new bead-based assay to measure levels of human tissue factor antigen in extracellular vesicles in plasma. Res Pract Thromb Haemost In press.
  10. Grover SP, Coughlin T, Fleifil S, Posma JJN, Heitmeier S, Spronk HHM, Owens AP III, Mackman N. Effect of combining aspirin and rivaroxaban on atherosclerosis in mice. Athero In press.
  11. Daugherty A, Hegele RA, Lu HS, Mackman N, Rader DJ, Weber C. Web of science’s citation median metrics overcome the major contraints of the journal impact factor. Arterioscler Thromb Vasc Biol. In press.
  12. Gunther RC, Bharathi V, Miles SA, Tumey LR, Schmedes CM, Tatsumi K, Bridges MD, Martinez D, Montgomery SA, Beck MA, Camerer E, Mackman N, Antoniak S. Myeloid protease-activated receptor-2 contributes to influenza A virus pathology in mice. Front Immunol 12:791017, 2021. PMID: 34925374.
  13. Kim SJ, Carestia A, McDonald B, Zucoloto AZ, Grosjean H, Davis RP, Turk M, Naumenko V, Antoniak S, Mackman N, Abdul-Cader MS, Abdul-Careem MF, Hollenberg MD, Jenne CN Platelet-mediated NET release amplifies coagulopathy and drives pathology during severe influenza infection. Front Immunol 12:772859, 2021, PMID: 34858432.
  14. Ehara H, Tatsumi K, Takafuji Y, Ishida M, Okada K, Mackman N, Kaji H. Role of tissue factor in delayed bone repair induced by diabetic state in mice. PloS One 2;16(12);e0260754, 2021. PMID: 34855855.
  15. Lee RH, Kawano T, Grover SP, Bharathi V, Martinez D, Cowley DO, Mackman N, Bergmeier W, Antoniak S. Genetic deletion of PAR4 results in reduced thrombosis and impaired hemostatic plug stability. J Thromb Haemost 20(20:422-433, 2021. PMID: 34689407.
  16. Hisada Y, Garratt KB, Maqsood A, Grover SP, Kawano T, Cooley BC, Erlich J, Moik F, Flick MJ, Pabinger I, Mackman N, Ay C. Plasminogen activator inhibitor 1 and venous thrombosis in pancreatic cancer. Blood Adv 5(2):487-495, 2021. PMID: 33496742.
  17. Hisada Y, Moser B, Kawano T, Revenko AS, Crosby JR, Spronk HM, Mackman N. The intrinsic pathway does not contribute to activation of coagulation in mice bearing human pancreatic tumors. Thromb Haemost 121(7):967-970, 2021. PMID: 33498089.
  18. Obermayer G, Afonyushkin T, Goderle L, Puhm F, Schrottmaier W, Taqi S, Schwameis M, Ay C, Pabinger I, Jilma B, Assinger A, Mackman N, Binder CJ. Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis. Blood 137(10):1406-1415, 2021. PMID: 3512411.
  19. Rosell A, Aguilera K, Hisada Y, Schmedes C, Mackman N, Wallen J, Lundstrom S, Thalin C. Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer. Sci Rep 11(1):5074, 2021. PMID: 33658563.
  20. Tawil N, Bassawon R, Meehan B, Nehme A, Montermini L, Gayden T, De Jay N, Spinelli C, Chennakrishnaiah S, Choi D, Adnani L, Zeinieh M, Jabado N, Kleinman CL, Witcher M, Riazalhosseini Y, Key NS, Schiff D, Grover SP, Mackman N, Couturier CP, Petrecca K, Suva ML, Patel A, Tirosh I, Najafabadi H, Rak J. Glioblastoma cell populations with distinct oncogenic programs release popoplanin as procoagulant extracellular vesicles. Blood Adv 5(6):1682-1694, 2021, PMID: 33720339.
  21. Avenick D, Kidd L, Istvan S, Dong F, Richter K, Edwards N, Hisada Y, Posma JJN, Massih CA, Mackman N. J Vet Emerg Crit Care 31(1):221-230, 2021. PMID: 33751799.
  22. Campbell RA, Hisada Y, Denorme F, Grover SP, Bouck EG, Middleton EA, Wolberg AS, Rondina MT, Mackman N. Comparison of the coagulopathies associated with COVID-19 and sepsis. Res Pract Thromb Haemost 5(4):e12525, 2021. PMID: 34027292.
  23. Yamakage S, Oe Y, Sato E, Okamoto K, Sekimoto A, Kumakura S, Sato H, Yoshida M, Nagasawa T, Miyazaki M, Ito S, Mackman N, Takahashi N. Myeloid cell-derived coagulation tissue factor is associated with renal tubular damage in mice fed an adenine diet. Sci Rep 11(1):12159, 2021. PMID: 34108522.
  24. Zhang Y, Cui J, Zhang G, Wu C, Abdel-Latif A, Smyth SS, Shiroishi T, Mackman N, Wei Y, Tao M, Li Z. Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Adv 5(12):2619-2623, 2021. PMID: 34152402.
  25. Cibi DM, Sandireddy R, Bogireddi H, Tee N, Ghani SASA, Singh BK, Mackman N, Singh MK, Singh A. Cardiac tissue factor regulates inflammation, hypertrophy, and heart failure in a mouse model of type 1 diabetes. Diabetes 70(9):2131-2146, 2021. PMID: 34155039.
  26. Subramaniam S, Ogoti Y, Hernandez I, Zogg M, Botros F, Burns R, DeRousse JT, Dockendorff C, Mackman N, Antoniak S, Fletcher C, Weiler H. A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv 5(13):2760-2774, 2021. PMID: 34242391.
  27. Bode MF, Schmedes CM, Egnatz GJ, Bharathi V, Hisada YM, Martinez D, Kawano T, Weithauser A, Rosenfeldt L, Rauch U, Palumbo JS, Antoniak S, Mackman N. Cell type-specific roles of PAR1 in Coxsachievirus B3 infection. Sci Rep 11(1):14264, 2021. PMID: 34253819.
  28. Moik F, Prager G, Thaler J, Posch F, Wiedemann S, Schramm T, Englisch C, Mackman N, Pabinger I, Ay C. Haemostatic biomarkers and venous thromboembolism are associated with mortality and response to chemotherapy in patients with pancreatic cancer. Arterioscler Thromb Vasc Biol. 41(11):2837-2847, 2021. PMID: 34470475
  29. Lundstrom A, Ziegler L, Havervall S, Rudberg AS, von Meijenfeldt F, Lisman T, Mackman N, Sanden P, Thalin C. Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers. J Med Virol 93(10):5908-5916, 2021. PMID: 34138483.
  30. von Meijenfeldt FA, Haverall S, Adelmeijer J, Lundstrom A, Magnusson M, Mackman N, Thalin C, Lisman T. COVID-19 is associated with an acquired factor XIII deficiency. Thromb Haemost 121(12): 1668-1669, 2021, PMID: 33742434.
  31. Antoniak S, Tatsumi K, Schmedes CM, Egnatz GJ, Auriemma AC, Bharathi V, Stokol T, Beck MA, Griffin JH, Palumbo JS, Mackman N. PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus. J Thromb Haemost 19(4):1103-1111. 2021. PMID:33346953.
  32. von Meijenfeldt FA, Havervall S, Adelmeijer J, Lundstrom A, Rudberg A-S, Magnusson M, Mackman N, Thalin C, Lisman T. Sustained prothrombotic changes in COVID-19 patients four months after hospital discharge. Blood Adv. 5(3):756-759, 2021. PMID: 33560386.
  33. von Meijenfeldt FA, Havervall S, Adelmeijer J, Lundstrom A, Rudberg A-S, Magnusson M, Mackman N, Thalin C, Lisman T. Elevated factor V activity and antigen levels in patients with COVID-19 are related to disease severity and 30-day mortality. A J Hemat 96(4):E98-E100, 2021. PMID: 33393103.
  34. Prasad JM, Negrón O, Du X, Mullins ES, Palumbo JS, Gilbertie JM, Höök M, Grover SP, Pawlinski R, Mackman N, Degen JL, Flick MJ. Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation. Proc Natl Acad Sci USA. 118(1):e2009837118, 2021. PMID:33443167.
  35. Maqsood A, Hisada Y, Garratt KB, Homeister J, Mackman N. Rivaroxaban does not affect growth of human pancreatic tumors in mice. J Thromb Haemost. 2019 Dec;17(12):2169-2173. doi: 10.1111/jth.14604. Epub 2019 Aug 26. PMID: 31393055; PMCID: PMC6893077.
  36. Tatsumi K, Hisada Y, Connelly AF, Buranda T, Mackman N. Patients with severe orthohantavirus cardiopulmonary syndrome due to Sin Nombre Virus infection have increased circulating extracellular vesicle tissue factor and an activated coagulation system. Thromb Res 179:31-33, 2019. PMID 31075699.
  37. Hisada Y, Grover SP, Maqsood A, Houston R, Ay C, Noubouossie DF, Cooley BC, Wallén H, Key NS, Thålin C, Farkas ÁZ, Farkas VJ, Tenekedjiev K, Kolev K, Mackman N. Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors. Haematologica 2019. In Press. PMID 31048354.
  38. Hisada Y, and Mackman N. Measurement of tissue factor activity in extracellular vesicles from human plasma. Res & Pract in Hemos & Thromb, Nov 20;3(1):44-48, 2018. PMID 30656275.
  39. Antoniak S, Tatsumi K, Schmedes CM, Grover SP, Pawlinski R, Mackman N. Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol. 2018 Sep;122:80-87. PMID 30098988
  40. Bode MF, Auriemma AC. Grover SP, Hisada Y, Rennie A, Bode WD, Vora R, Subramanian S, Cooley B, Andrade-Gordon P, Antoniak, S, Mackman N. The factor Xa inhibitor rivaroxaban reduced cardiac dysfunction in a mouse model of myocardial infarction. Thromb Res. 17:128-134, 2018. PMID 29843086.
  41. Hisada T, Thalin C, Kundstrom S, Wallen H, Mackman, N. Comparison of microvesicle tissue factor activity in non-cancer severely ill patients and cancer patients. Thromb Res 165:1-5, 2018. PMID 29539580.
  42. Hisada Y, Ay C, Cooley BC, Mackman N. Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size. J Throm Haemost 15(11):2208-2217, 2017. PMID 28834179.
  43. Ay C, Hisada Y, Cooley B, Mackman N. Factor XI deficient mice exhibit increased bleeding after injury to the saphenous vein. J Thromb Haemost 15(9):1928-1833, 2017. PMID 28677246.
  44. Hisada Y, Auriemma AC, Alexander W, Ay C, Mackman N. Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy. Thromb Res. 150:65-72, 2016. PMID 28043041.
  45. Antoniak S, Tatsumi K, Bode M, Vanja S, Williams JC, Mackman N. Protease-activated receptor 1 enhances poly I:C induction of the antiviral response in macrophages and mice. Innate Immunol. 9(2):181-192, 2017. PMID 27820939.
  46. Bode MF, Mackman N. A combined deficiency of tissue factor and PAR-4 is associated with fatal hemorrhage in mice. Thromb Res. 146:46-50, 2016. PMID 27586081.
  47. Antoniak S, Cardenas JC, Buczek LJ, Church FC, Mackman N, Pawlinski R. Protease-activated receptor 1 contributes to angiotensin II-induced cardiovascular remodeling and inflammation. Cardiology. 136(4);258-268., 2016. PMID 27880950.
  48. Tatsumi K, Antoniak S, Subramaniam S, Gondouin B, Neidrich SD, Beck MA, Mickelson J, Monroe DM 3rd, Bastarache JA, Mackman N. Anticoagulation increases alveolar hemorrhage in mice infection with influenza A. Physiol Rep. 4(24) e13071, 2016. PMID 28003564.
  49. Geddings JE, Hisada Y, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N. Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice. J Thromb Haemost. 14 (1), 153-66. 2016. PMID:
  50. Rondina MT, Tatsumi K, Bastarache JA, Mackman N. Microvesicle tissue factor activity and interleukin-8 levels are associated with mortality in patients with influenza A/H1N1 infection. Crit Care Med. 44(7):e574-578,2016. PMID:
  51. Antoniak S, Tatsumi K, Hisada Y, Milner JJ, Neidich SD, Shaver CM, Pawlinski R, Back MA, Bastarachi JA, Mackman, N. Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice. J Thomb Haemost. 14(6):1238-1248, 2016. PMID 26947929.
  52. Rautou PE, Tatsumi K, Antoniak S, Owens AP 3rd, Sparkenbaugh E, Holle LA, Wolberg AS, Kopec AK, Pawlinski R, Luyendyk JP, Mackman N. Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury. Hepatol. 64(1):53-9, 2015. PMID 26325534.
  53. Owens AP 3rd, Edwards TL, Antoniak S, Geddings JE, Jahangir E, Wei WQ, Denny JC, Boulaftali Y, Bergmeier W, Daugherty A, Sampson UK, Mackman N. Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 35(9): 3032-2041. 2015. PMID 26139462.
  54. Kidd L, Geddings J, Hisada Y, Sueda M, Concannon T, Nichols T, Merricks E, Mackman N. Procoagulant microparticles in dogs with immune-mediated hemolytic anemia. J Vet Intern Med. 29(3):908-916. 2015. PMID 25871966.
  55. Tatsumi K, Antoniak S, Monroe DM 3rd, Khorana AA, Mackman N. Evaluation of a new commercial assay to measure microparticle tissue factor activity in plasma: communication from the SSC of the ISTH. J Thromb Haemost. 12(11):1932-1934. 2014. PMID 25186801.
  56. Rautou PE, Vion AC, Luyendyk JP, Mackman N. Circulating microparticle tissue factor activity is increased in patients with cirrhosis. 60(5): 1793-1795, 2014. PMID 24470301.