Skip to main content
Click here is the most up-to-date list of publication


Biochemical and rheological analysis of human colonic culture mucus reveals similarity to gut mucus
RL Howard, M Markovetz, Y Wang, C Ehre, SZ Sheikh, NL Allbritton, …
Biophysical Journal 120 (23), 5384-5394
OCT particle tracking velocimetry of biofluids in a microparallel plate strain induction chamber
KJ Oeler, DB Hill, AL Oldenburg
Journal of biomedical optics 26 (9), 096005

Molecular dynamics simulations to explore the structure and rheological properties of normal and hyperconcentrated airway mucus

AG Ford, XZ Cao, MJ Papanikolas, T Kato, RC Boucher, MR Markovetz, …
Studies in Applied Mathematics
PR Sears, XM Bustamante-Marin, H Gong, MR Markovetz, R Superfine, …
Biophysical Journal 120 (8), 1387-1395
Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration
CB Morrison, KM Shaffer, KC Araba, MR Markovetz, JA Wykoff, …
European Respiratory Journal

Antibiofilm and mucolytic action of nitric oxide delivered via gas or macromolecular donor using in vitro and ex vivo models

KR Rouillard, DB Hill, MH Schoenfisch
Journal of Cystic Fibrosis 19 (6), 1004-1010

Pseudomonas aeruginosa Biofilm Eradication via Nitric Oxide-Releasing Cyclodextrins

KR Rouillard, MR Markovetz, LG Bacudio, DB Hill, MH Schoenfisch
ACS Infectious Diseases 6 (7), 1940-1950
Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds.

Schiller, J. L., Fogle, M. M., Bussey, O., Kissner, W. J., Hill, D. B., and Lai, S. K.
Acta Biomaterials. 2020.

Airway mucus hyperconcentration in non-cystic fibrosis bronchiectasis.

Ramsey, K., Chen, A., Radicioni, G., Lourie, R., Martin, M., Broomfield, A., Yong, H., Hasnain, S., Radford-Smith, G., Simms, L., Burr, L., Thornton, D. J., Bowler, S., Livengood, S., Ceppe, A., Knowles, M., Donaldson, S. H., Hill, D., Ehre, C., Button, B., Kesimer, M., McGuckin, M., and Boucher, R.
American Journal of Respiratory and Critical Care Medicine. 2019.

Endotracheal tube mucus as a source of airway mucus for rheological study.

Markovetz, M. R., Subramani, D. B., Kissner, W. J., Morrison, C. B., Garbarine, I. C., Ghio, A., Ramsey, K. A., Arora, H., Kumar, P., and Hill, D. B.
American Journal of Physiology-Lung Cellular and Molecular Physiology 317, L498-L509. 2019. 

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Esther, C. R., Jr., Muhlebach, M. S., Ehre, C., Hill, D., Wolfgang, M., Kesimer, M., Ramsey, K., Markovetz, M., Forest, G., Seim, I., Zorn, B., Morrison, C. B., Delion, M. F., Turkovic, L., Ranganath, S., Stick, S., and Boucher, R.
Science Translational Medicine 11, eaav3488. 2019.

An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases.

Ehre, C., Rushton, Z. L., Wang, B., Hothem, L. N., Morrison, C. B., Fontana, N. C., Markovetz, M. R., Delion, M. F., Kato, T., Villalon, D., Thelin, W. R., Esther, C. R., Jr., Hill, D. B., Grubb, B. R., Livraghi-Butrico, A., Donaldson, S. H., and Boucher, R. C.
Am J Respir Crit Care Med 199, 171-180. 2019.

Nitric oxide-releasing alginates as mucolytic agents.

Ahonen, M. J. R., Hill, D., and Schoenfisch, M. H.
ACS Biomaterials Science & Engineering. 2019.

Clinical Application of Polysialylated Therapeutic Proteins.

Meng, H., Lockshin, C., Jain, S., Shaligram, U., Martinez, J., Genkin, D., Hill, D., Ehre, C., Clark, D., and Hoppe, H.
Recent Patents on Drug Delivery & Formulation. 2018.

Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH.

Hill, D. B., Long, R. F., Kissner, W. J., Atieh, E., Garbarine, I. C., Markovetz, M. R., Fontana, N. C., Christy, M., Habibpour, M., and Tarran, R.
European Respiratory Journal 52, 1801297. 2018.

Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice.Nitric oxide-releasing alginates as mucolytic agents.

Hancock, L. A., Hennessy, C. E., Solomon, G. M., Dobrinskikh, E., Estrella, A., Hara, N., Hill, D. B., Kissner, W. J., Markovetz, M. R., Grove Villalon, D. E., Voss, M. E., Tearney, G. J., Carroll, K. S., Shi, Y., Schwarz, M. I., Thelin, W. R., Rowe, S. M., Yang, I. V., Evans, C. M., and Schwartz, D. A.
Nat Commun 9, 5363. 2018.

Buffer drains and mucus is transported upward in a tilted mucus clearance assay.

Carpenter, J., Lynch, S. E., Cribb, J. A., Kylstra, S., Hill, D. B., and Superfine, R.
American Journal of Physiology-Lung Cellular and Molecular Physiology 315, L910-L918. 2018.

Rheology of Mucus Treated with Nitric Oxide-Releasing Alginates.

Ahonen, M., Hill, D., and Schoenfisch, M.
Biomaterials Science. 2018.

Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer.

Youngren-Ortiz, S. R., Hill, D. B., Hoffmann, P. R., Morris, K. R., Barrett, E. G., Forest, M. G., and Chougule, M. B.
J Aerosol Med Pulm Drug Deliv 30, 299-321. 2017.

Role of Nitric Oxide-Releasing Chitosan Oligosaccharides on Mucus Viscoelasticity.

Reighard, K. P., Ehre, C., Rushton, Z. L., Ahonen, M. J. R., Hill, D. B., and Schoenfisch, M. H.
ACS Biomater Sci Eng 3, 1017-1026 . 2017.

The sialic acid to urea ratio as a measure of airway surface hydration.

Esther, C. R., Hill, D. B., Button, B., Shi, S., Jania, C. M., Duncan, E. A., Doerschuk, C. M., Chen, G., Ranganathan, S., and Stick, S. M.
American Journal of Physiology-Lung Cellular and Molecular Physiology, ajplung. 00398.02016. 2017.

Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT.

Blackmon, R., Kreda, S., Sears, P., Chapman, B., Hill, D., Tracy, J., Ostrowski, L., and Oldenburg, A.
Nanoscale 9, 4907-4917. 2017.

Modeling and Simulation of Mucus Flow in Human Bronchial Epithelial Cell Cultures – Part I: Idealized Axisymmetric Swirling Flow.

Vasquez, P. A., Jin, Y., Palmer, E., Hill, D., and Forest, M. G.
Plos Computational Biology 12, e1004872. 2016.

Maximum likelihood estimation for single particle, passive microrheology data with drift.

Mellnik, J. W. R., Lysy, M., Vasquez, P. A., Pillai, N. S., Hill, D. B., Cribb, J., McKinley, S. A., and Forest, M. G.
Journal of Rheology 60, 379-392. 2016.

Model comparison and assessment for single particle tracking in biological fluids.

Lysy, M., Pillai, N. S., Hill, D. B., Forest, M. G., Mellnik, J. W., Vasquez, P. A., and McKinley, S. A.
Journal of the American Statistical Association 111, 1413-1426. 2016.

Disruption and eradication of P. aeruginosa biofilms using nitric oxide-releasing chitosan oligosaccharides.

Reighard, K. P., Hill, D. B., Dixon, G. A., Worley, B. V., and Schoenfisch, M. H.
Biofouling 31, 775-787. 2015.

Micro-heterogeneity metrics for diffusion in soft matter.

Mellnik, J., Vasquez, P. A., McKinley, S. A., Witten, J., Hill, D. B., and Forest, M. G.
Soft Matter 10, 7781-7796. 2014.

Pulmonary fluid flow challenges for experimental and mathematical modeling.

Levy, R., Hill, D. B., Forest, M. G., and Grotberg, J. B.
Integr Comp Biol 54, 985-1000. 2014.

A Biophysical Basis for Mucus Solids Concentration as a Candidate Biomarker for Airways Disease,

Hill, D. B., Vasquez, P. A., Mellnik, J., McKinley, S. A., Vose, A., Mu, F., Henderson, A. G., Donaldson, S. H., Alexis, N. E., Boucher, R. C., and Forest, G.
PLOS ONE 9, e87681 %@ 81932-86203. 2014.

Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography.

Chhetri, R. K., Blackmon, R. L., Wu, W. C., Hill, D. B., Button, B., Casbas-Hernandez, P., Troester, M. A., Tracy, J. B., and Oldenburg, A. L.
Proc Natl Acad Sci U S A 111, E4289-4297. 2014.

A new twist on Stokes’ second problem: Partial penetration of nonlinearity in sheared viscoelastic layers.

Vasquez, P. A., Jin, Y., Vuong, K., Hill, D. B., and Forest, M. G.
Journal of Non-Newtonian Fluid Mechanics 196, 36-50 . 2013.

Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells.

Seagrave, J., Albrecht, H. H., Hill, D. B., Rogers, D. F., and Solomon, G.
Respir Res 13, 98. 2012.

Monitoring airway mucus flow and ciliary activity with optical coherence tomography.

Oldenburg, A. L., Chhetri, R. K., Hill, D. B., and Button, B.
Biomed Opt Express 3, 1978-1992. 2012.

Spatial Stress and Strain Distributions of Viscoelastic Layers in Oscillatory Shear.

Lindley, B. S., Forest, M. G., Smith, B. D., Mitran, S. M., and Hill, D. B.
Math Comput Simul 82, 1249-1257. 2012.

Statistical challenges in microrheology.

Didier, G., McKinley, S. A., Hill, D. B., and Fricks, J.
J Time Ser Anal 33, 724-743. 2012.

A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.

Button, B., Cai, L. H., Ehre, C., Kesimer, M., Hill, D. B., Sheehan, J. K., Boucher, R. C., and Rubinstein, M.
Science 337, 937-941. 2012.

Force generation and dynamics of individual cilia under external loading.

Hill, D. B., Swaminathan, V., Estes, A., Cribb, J., O’Brien, E. T., Davis, C. W., and Superfine, R.
Biophys J 98, 57-66. 2010.

Magnet polepiece design for uniform magnetic force on superparamagnetic beads.

Fallesen, T., Hill, D. B., Steen, M., Macosko, J. C., Bonin, K., and Holzwarth, G.
Review of scientific instruments 81, 074303. 2010.

Stress communication and filtering of viscoelastic layers in oscillatory shear.

Lindley, B., Howell, E. L., Smith, B. D., Rubinstein, G. J., Forest, M. G., Mitran, S. M., Hill, D. B., and Superfine, R.
Journal of Non-Newtonian Fluid Mechanics 156, 112-120. 2009.

Extensions of the Ferry shear wave model for active linear and nonlinear microrheology.

Mitran, S. M., Forest, M. G., Yao, L., Lindley, B., and Hill, D. B.
J Nonnewton Fluid Mech 154, 120-135. 2008.

Motion‐enhanced, differential interference contrast (MEDIC) microscopy of moving vesicles in live cells: VE‐DIC updated.

Hill, D. B., Macosko, J. C., and Holzwarth, G. M.
Journal of Microscopy 231, 433-439. 2008.

A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.

Matsui, H., Wagner, V. E., Hill, D. B., Schwab, U. E., Rogers, T. D., Button, B., Taylor, R. M., Superfine, R., Rubinstein, M., and Iglewski, B. H.
Proceedings of the National Academy of Sciences 103, 18131-18136. 2006.

Fast vesicle transport in PC12 neurites: velocities and forces.

Hill, D., Plaza, M., Bonin, K., and Holzwarth, G.
European Biophysics Journal 33, 623-632. 2004.

Forces required of kinesin during processive transport through cytoplasm.

G., Bonin, K., and Hill, D. B.
Biophysical Journal 82, 1784-1790. 2002.

Differential Interference Contrast Microscopy Gets Supercharged.

Holzwarth, G., and Hill, D.

Polarization-modulated differential-interference contrast microscopy with a variable retarder.

Holzwarth, G. M., Hill, D. B., and McLaughlin, E. B.
Appl. Optics 39, 6288-6294. 2000.