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Marsico Lung Institute/UNC Cystic Fibrosis Center

Pulmonary Fibrosis Model

A model for pulmonary fibrosis in the lungs of mice.

The Chen lab, headed by Gang Chen, PhD, presents images displaying reduced lung volume in transgenic mice after pulmonary injury. Reduction of lung volume is a predictor of lung function loss, which often occurs during pulmonary fibrosis. The pulmonary fibrosis model was developed by exposing control and transgenic mice, which overexpressed the Xbp1S transgene in Club cells, to intrapulmonary bleomycin. To assess the progression of the disease in live animals, in vivo CT imaging was performed four weeks after induction of pulmonary injury. The imaging was conducted using the preclinical Quantum-GX2 microCT system. Lung volume was quantified through 3D reconstruction, employing anthropometry techniques. LV: lung volume

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