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Marsico Lung Institute/UNC Cystic Fibrosis Center

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SMM-exposed HBE Overproducing Mucus

SMM-Exposed HBE Overproducing Mucus.

“Mucus overproduction and hyper-secretion by a well-differentiated primary culture of human bronchial epithelia in response to mucosal exposure to supernatant from mucopurulent material (SMM) from human cystic fibrosis airways. Image depicts the Alcian Blue-Periodic Acid Schiff stain of mucins. The SMM model, developed in Dr. Ribeiro’s laboratory, has been key for studying in vitro functional alterations of airway epithelia relevant to the native airway epithelia of people with cystic fibrosis.”

This image was the cover photo for the February 2018 issue of American Journal of Respiratory and Critical Care Medicine (Vol. 197, No. 4).

Credit: Abdullah LH, Coakley R, Webster MJ, Zhu Y, Tarran R, Radicioni G, Kesimer M, Boucher RC, Davis CW, Ribeiro CMP. Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia. Am J Respir Crit Care Med. 2018 Feb 15;197(4):481-491. doi: 10.1164/rccm.201706-1139OC. PMID: 29099608; PMCID: PMC5821906.

Image contributed by Kimberlie Burns, Lubna Abdullah, and Carla Ribeiro (carla_ribeiro@med.unc.edu).


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