Janet Rubin, MD

Sarah Graham Kenan Distinguished Professor of Medicine, Division of Endocrinology and Metabolism
Joint Professor, Pediatrics and Pharmacology
Adjunct Professor, Bioengineering
Vice Chair for Research, Department of Medicine

Best Doctors in America 2017-18

Specialty Areas

Osteoporosis, metabolic bone disease, molecular research.

Education and Experience

MD: Brown University, 1980; Intern and Resident: Northwestern University Medical Center, 1980-1983; Endocrinology and Metabolism Fellowship: University of California, San Diego, 1980-1983; Instructor Medicine: UCSD, 1983-1986; Faculty and Professor of Medicine with tenure: Emory University, 1986-2006; Physican: VAMC Atlanta, 1986-2006; Professor of Medicine with tenure: University of North Carolina, 2006-present.

Dr. Rubin practices Endocrinology in the Meadowmont Endo/Diabetes Center with a specialty in Osteoporosis and metabolic bone disease, and is responsible for bone density testing there.

Dr. Rubin investigates the controls over bone remodeling, in particular exercise and mechanical force effects on the cell cytoskeleton. At the University Dr Rubin continues her decades long research into bone remodeling. The laboratory is currently investigating how bone marrow stem cells are directed to become osteoblasts or adipocytes, with a particular interest in how exercise regulates this divergent differentiation through the cellular cytoskeleton. Her research is funded by the NIH. Dr. Rubin’s lab recently published a case detailing an important side effect of iron administration, FGF23 based rickets, which was written with a medical intern at UNC.

Dr. Rubin is also active in DOM leadership as the Vice Chair for Research. Her interests are in junior faculty research development, and promotion of research throughout the Department.

Selected Bibliography

Sen B, Uzer G, Samsonraj RM, Xie Z, McGrath C, Styner M, Dudakovic D, van Wijnen AJ, Rubin J 2017 Intranuclear actin structure modulates mesenchymal stem cell differentiation, Stem Cells, 35(6):1624-1635

Klein KR, Asaad S, Econs M, Rubin J 2018 Severe FGF23 based hypophosphatemic osteomalacia due to ferric carboxymaltose administration, BMJ Case Rep Jan3 doi: 10.1136/bcr-2017-222851

Styner M, Pagnotti GM, McGrath C, Wu X, Sen B, Uzer G, Xie Z, Zong X, Styner MA, Rubin CT, Rubin J 2017 Exercise decreases marrow adipose tissue through b-oxidation, J Bone Miner Research, 32:1692-1702.

Uzer G, Rubin CT, Rubin J 2016 Cell mechanosensitivity is enabled by the LINC nuclear complex. Curr Mol Biol Rep. 2(1):36-47

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