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You Li, PhD | Division of Infectious Diseases

You Li, PhD

Assistant Professor of Medicine

Contact Information


8032 Burnett-Womack Bldg
160 Dental Cir
Chapel Hill, NC 27599


You Li, PhD

Assistant Professor of Medicine

Areas of Interest

Hepatoviruses, picornaviruses, viral-host interactions


Li’s current research focuses on host factors of hepatitis A virus (HAV) infection. Usually well controlled by sanitation and vaccines, HAV has re-emerged as a public health threat in recent years with widespread outbreaks. His work suggests HAV replication is dependent on the cellular TRAMP-like complex ZCCHC14-TENT4. Small molecule inhibitors of TENT4 dramtically suppress HAV replication in vitro and in mouse models of hepatits A. Li is investigating the mechanisms underlying the essential role of TENT4 proteins in HAV life cycle and the potential application of TENT4 inhibitors as therapeutics for treatment of severe hepatitis A infection.

  • Undergraduate

    Tsinghua University, Beijing, China

  • Graduate

    Rutgers University