Bergmeier Lab has a new publication in Blood: Functional redundancy between RAP1 isoforms in murine platelet production and function. This work demonstrates a crucial role for the small GTPase RAP1 in platelet production and function. Using mice deficient in one or both RAP1 isoforms, RAP1A and RAP1B, we were able to demonstrate that (1) megakaryocytes … Read more

Silvio Antoniak, PhD, Assistant Professor in the Department of Pathology and Laboratory Medicine and Member of the McAllister Heart Institute, has been awarded a $1.9-million, five-year grant from the NIH-NHLBI to investigate the potential therapeutic approach in inhibiting the coagulation factor Xa or PAR2 in viral myocarditis and H1N1 influenza A virus infection. The project … Read more

Griffith Lab has received $2.78M funding from the National Institutes of Health for a new 5-year project: Multiscale Modeling of Clotting Risk in Atrial Fibrillation. This is a multi-institutional project involving UNC, Duke, and the University of Utah. UNC co-investigators include Dr. John Vavalle from the Division of Cardiology.

Li Qian, PhD, Associate Professor of Pathology, member of the McAllister Heart Institute, has received the 2018 Transformational Project Award from the American Heart Association (AHA) with 3 years funding in the amount of $300,000 to support Qian Lab’s continued effort in using reprogramming approaches to mend broken hearts. Dr. Qian’s work in cardiac reprogramming … Read more

Li Wang, PhD, Research Associate in the Qian lab at McAllister Heart Institute has received a Career Development Award from AHA with 3 years funding of $231,000 to support her research project “Role of Autophagy in Direct Cardiac Reprogramming.” Read more about Dr. Wang and her research.

It is with great sadness that we share the news that our friend and benefactor, Dr. Hugh A. “Chip” McAllister, Jr. MD ’66, passed away at his home in Houston, Texas this past Friday, June 15. All of us have been and will continue to be inspired by Chip’s vision and passion to build the … Read more

“Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations,” with Dr. Jonathan Schisler, assistant professor in the Department of Pharmacology and McAllister Heart Institute, leading a multidisciplinary team, has been selected for the cover of the June issue of the Journal of Personalized Medicine. This research examines the applicability of precision medicine to … Read more

Matthew Combs of Taylor Lab has received an AHA Predoctoral Fellowship for his project titled “A role for GRAF1 in mitochondrial clearance and perinatal metabolic reprogramming.”

Two genomic-based studies from the Heart Healthy Lenoir study were published in the last month. Heart Healthy Lenoir was a multidisciplinary research project that aimed to reduce cardiovascular disease in Lenoir County, North Carolina by developing new approaches to care, from prevention to treatment. The lead investigator of the Heart Healthy Lenoir genomics study is … Read more

A multidisciplinary team from UNC’s Departments of Nutrition, Pharmacology, Pathology, and the McAllister Heart Institute have published new findings on genetics and metabolism in the Journal of the American Heart Association. The paper, “Modeling the Transition from Decompensated to Pathological Hypertrophy,” is a collaboration by Florencia Pascual (Nutrition), Jonathan C. Schisler (Pharmacology, McAllister Heart Institute), … Read more