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Ilona Jaspers, PhD

Professor

Pediatrics, Microbiology & Immunology, and Env. Sci. & Engineering

Director; Curriculum in Toxicology & Environmental Medicine
Director; Center for Env. Med. Asthma & Lung Biology

Rm 4004B

Mary Ellen Jones Buidling

Research

My research focuses on the adverse effects and toxicity of inhaled pollutants, especially how it pertains to modification of respiratory host defense responses and mucosal inflammation. Specifically, through NIEHS, NHLBI, EPA, DoD, and FDA/NIH funding, my lab examines how inhaled toxicants modify respiratory antiviral host defense responses using several translational research models, including organotypic models of the respiratory mucosa and human controlled exposure studies. We are particularly interested in how inhaled toxicants, such as ambient air pollutants, woodsmoke, cigarette smoke, military burn pits, and e-cigarettes, modify respiratory innate immune responses resulting in enhanced susceptibility to microbial infections using human in vivo and in vitro experimental models. I have broad experience in developing non-invasive techniques to obtain human clinical samples and immunophenotyping mucosal immune cells obtained from human volunteers, which have been incorporated into clinical studies examining effects of inhaled toxicants on respiratory health. I have extensively participated in cross-disciplinary translational research teams, providing expertise in toxicology and analyses of human clinical samples as well as in vitro exposure models, thus linking mechanistic understanding of pollutant-induced modifications of cellular host defense responses to clinical observations in humans in vivo.

Publications

Brocke SA, Billings GT, Taft-Benz S, Alexis NE, Heise MT, Jaspers I. Woodsmoke particulates alter expression of antiviral host response genes in human nasal epithelial cells infected with SARS-CoV-2 in a sex-dependent manner.bioRxiv [Preprint]. 2021 Aug 25:2021.08.23.457411. doi:10.1101/2021.08.23.457411. PMID: 34462747; PMCID: PMC8404889.

Rebuli ME, Brocke SA, Jaspers I. Impact of inhaled pollutants on response to viral infection in controlled exposures. J Allergy Clin Immunol. 2021 Jul 10:S0091-6749(21)01060-5. doi: 10.1016/j.jaci.2021.07.002. Epub ahead of print. PMID: 34252446.

Perryman A, Speen AM, Kim HH, Hoffman JR, Clapp PW, Rivera Martin W, Snouwaert JN, Koller BH, Porter NA, Jaspers I. Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation. Am J Respir Cell Mol Biol. 2021 Jun 14. doi: 10.1165/rcmb.2021-0032OC. Epub ahead of print. PMID: 34126877.

Rebuli ME, Glista-Baker E, Hoffman JR, Duffney PF, Robinette C, Speen AM, Pawlak EA, Dhingra R, Noah TL, Jaspers I. Electronic-Cigarette Use Alters Nasal Mucosal Immune Response to Live-attenuated Influenza Virus. A Clinical Trial. Am J Respir Cell Mol Biol. 2021 Jan;64(1):126-137. doi: 10.1165/rcmb.2020-0164OC. PMID: 33095645; PMCID: PMC7781000.

Duffney PF, Kim HH, Porter NA, Jaspers I. Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors. J Biol Chem. 2020 Sep 4;295(36):12727-12738. doi: 10.1074/jbc.RA120.013699. Epub 2020 Jul 20. PMID: 32690608; PMCID: PMC7476716.

Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH 3rd, Kato T, Lee RE, Yount BL, Mascenik TM, Chen G, Olivier KN, Ghio A, Tse LV, Leist SR, Gralinski LE, Schäfer A, Dang H, Gilmore R, Nakano S, Sun L, Fulcher ML, Livraghi-Butrico A, Nicely NI, Cameron M, Cameron C, Kelvin DJ, de Silva A, Margolis DM, Markmann A, Bartelt L, Zumwalt R, Martinez FJ, Salvatore SP, Borczuk A, Tata PR, Sontake V, Kimple A, Jaspers I, O’Neal WK, Randell SH, Boucher RC, Baric RS. SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. Cell. 2020 Jul 23;182(2):429-446.e14. doi: 10.1016/j.cell.2020.05.042. Epub 2020 May 27. PMID: 32526206; PMCID: PMC7250779.

Escobar YH, Nipp G, Cui T, Petters SS, Surratt JD, Jaspers I. <i>In Vitro</i> Toxicity and Chemical Characterization of Aerosol Derived from Electronic Cigarette Humectants Using a Newly Developed Exposure System. Chem Res Toxicol. 2020 Jul 20;33(7):1677-1688. doi: 10.1021/acs.chemrestox.9b00490. Epub 2020 Apr PMID: 32223225.

Clapp PW, Peden DB, Jaspers I. E-cigarettes, vaping-related pulmonary illnesses, and asthma: A perspective from inhalation toxicologists. J Allergy Clin Immunol. 2020 Jan;145(1):97-99. doi: 10.1016/j.jaci.2019.11.001. Epub 2019 Nov 9. PMID: 31715190; PMCID: PMC7081413.

Bradford LE, Rebuli ME, Ring BJ, Jaspers I, Clement KC, Loughlin CE. Danger in the vapor? ECMO for adolescents with status asthmaticus after vaping. J Asthma. 2020 Nov;57(11):1168-1172. doi: 10.1080/02770903.2019.1643361. Epub 2019 Jul 27. PMID: 31352844.10: Hickman E, Herrera CA, Jaspers I. Common E-Cigarette Flavoring Chemicals Impair Neutrophil Phagocytosis and Oxidative Burst. Chem Res Toxicol. 2019 Jun 17;32(6):982-985. doi: 10.1021/acs.chemrestox.9b00171. Epub 2019 May 29. PMID: 31117350; PMCID: PMC6626492.

Rebuli ME, Speen AM, Martin EM, Addo KA, Pawlak EA, Glista-Baker E, Robinette C, Zhou H, Noah TL, Jaspers I. Wood Smoke Exposure Alters Human Inflammatory Responses to Viral Infection in a Sex-Specific Manner. A Randomized, Placebo-controlled Study. Am J Respir Crit Care Med. 2019 Apr 15;199(8):996-1007. doi: 10.1164/rccm.201807-1287OC. PMID: 30360637; PMCID: PMC6467301.

Chason KD, Jaspers I, Parker J, Sellers S, Brighton LE, Hunsucker SA, Armistead PM, Fischer WA 2nd. Age-Associated Changes in the Respiratory Epithelial Response to Influenza Infection. J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1643-1650. doi: 10.1093/gerona/gly126. PMID: 29878083; PMCID: PMC6230210.

Rebuli ME, Pawlak EA, Walsh D, Martin EM, Jaspers I. Distinguishing Human Peripheral Blood NK Cells from CD56<sup>dim</sup>CD16<sup>dim</sup>CD69<sup>+</sup>CD103<sup>+</sup> Resident Nasal Mucosal Lavage Fluid Cells. Sci Rep. 2018 Feb 21;8(1):3394. doi: 10.1038/s41598-018-21443-5. PMID: 29467466; PMCID: PMC5821812.

Clapp PW, Pawlak EA, Lackey JT, Keating JE, Reeber SL, Glish GL, Jaspers I. Flavored e-cigarette liquids and cinnamaldehyde impair respiratory innate immune cell function. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L278-L292. doi: 10.1152/ajplung.00452.2016. Epub 2017 May 11. PMID: 28495856; PMCID: PMC5582929.

Walsh DM, McCullough SD, Yourstone S, Jones SW, Cairns BA, Jones CD, Jaspers I, Diaz-Sanchez D. Alterations in airway microbiota in patients with PaO2/FiO2 ratio ≤ 300 after burn and inhalation injury. PLoS One. 2017 Mar 30;12(3):e0173848. doi: 10.1371/journal.pone.0173848. PMID: 28358811; PMCID:PMC5373524.

Rebuli ME, Speen AM, Clapp PW, Jaspers I. Novel applications for a noninvasive sampling method of the nasal mucosa. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L288-L296. doi: 10.1152/ajplung.00476.2016. Epub 2016 Dec 23. PMID: 28011618; PMCID: PMC5336583.

Speen AM, Kim HH, Bauer RN, Meyer M, Gowdy KM, Fessler MB, Duncan KE, Liu W, Porter NA, Jaspers I. Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS. J Biol Chem. 2016 Nov 25;291(48):25192-25206. doi: 10.1074/jbc.M116.732362. Epub 2016 Oct 4. PMID: 27703007; PMCID: PMC5122785.

Martin EM, Clapp PW, Rebuli ME, Pawlak EA, Glista-Baker E, Benowitz NL, Fry RC, Jaspers I. E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette

smoke. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L135-44. doi: 10.1152/ajplung.00170.2016. Epub 2016 Jun 10. PMID: 27288488; PMCID: PMC4967187.

Pawlak EA, Noah TL, Zhou H, Chehrazi C, Robinette C, Diaz-Sanchez D, Müller L, Jaspers I. Diesel exposure suppresses natural killer cell function and resolution of eosinophil inflammation: a randomized controlled trial of exposure in allergic rhinitics. Part Fibre Toxicol. 2016 May 6;13(1):24. doi: 10.1186/s12989-016-0135-7. PMID: 27154411; PMCID: PMC4859992.

Müller L, Meyer M, Bauer RN, Zhou H, Zhang H, Jones S, Robinette C, Noah TL, Jaspers I. Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study. PLoS One. 2016 Jan 28;11(1):e0147742. doi: 10.1371/journal.pone.0147742. PMID: 26820305; PMCID: PMC4731143.

Link to My Bibliography