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Rita Tamayo, PhD

Professor
6206 Marsico Hall

Research

Gene regulation and virulence mechanisms of intestinal pathogens

The goal of my laboratory’s research is to determine how Clostridioides difficile colonizes the mammalian intestine, regulates the production of virulence factors, and transmits between hosts. Our current focus is on the mechanisms employed by C. difficile to generate a phenotypically heterogeneous population that is better able to adapt to environmental stresses. We are particularly interested in the contributions of intracellular signaling molecules (c-di-GMP, c-di-AMP) and phase variation to phenotypic heterogeneity, and how these mechanisms influence C. difficile virulence and disease outcome. Through our research, trainees in the lab gain expertise in bacterial genetics, molecular biology, second messenger signaling, protein biochemistry, animal models of disease, and more.

For more information about our research and team, please visit www.TamayoLab.com

Follow us on Twitter @TamayoLab!

Link to My Bibliography