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Exosomes are small (~30-150 nanometers) vesicular bodies secreted by cells. Exosomes play important roles in cellular communication through the cargo they carry from donor cell to recipient cell. This cargo can include nucleic acids such as mRNA and miRNA, protein folding chaperones, and biologically active enzymes. Ongoing research is focusing on using exosomes as potential biomarkers, as their composition is known to undergo changes during times of stress.

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(Above) Short movie showing the movement of exosomes purified from BCBL-1 B-cells. Brownian motion can be used to calculate the relative diameter of each individual particle, and in turn, calculate the mean size of particles in the population. The faster the movement, the smaller the particle.

 

RPM