- This event has passed.
Dissertation Seminar- Christof Smith
February 22, 2019 @ 2:00 pm - 3:30 pm
Christof Smith
“Adaptive immunity and the tumor immune microenvironment.”
Friday, February 22, 2019
2:00 p.m.
6004 Marsico Hall
Dissertation Advisor: Dr. Jonathan Serody
Presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy
*****
Christof Smith
Abstract
The adaptive immune system is essential for production of anti-tumor immune responses, with the majority of current immunotherapeutics designed to modulate the interaction between adaptive immunity and tumor cells within the tumor-immune microenvironment. This dissertation addresses three translational goals regarding our understanding and modulation of anti-tumor adaptive immunity: 1) Improvement of understanding for existing immunotherapies such as checkpoint inhibitor therapy; 2) Improvement of efficacy for novel immunotherapeutics currently in development including tumor neoantigen vaccines; and 3) Development of next-generation immunotherapies through identification of novel anti-tumor vaccine targets, as well as development of diagnostic tools including biomarkers of immunotherapy response and immune-imaging modalities.
