In this new mBio article, systems biology meets viral pathogenesis as the Baric lab compares infections by highly pathogenic H5N1 avian influenza (HPAI) A virus, 2009 pandemic H1N1, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV). They demonstrate the existence of unique and common viral strategies for controlling interferon-stimulated genes during acute respiratory infection. See the article at the link below.