Selected Publications

Thiono DJ, Samaras D, Phan TTN, Zhu DR, Shah RP, Castillo I, Forsberg LJ, Premkumar L, Baric RS, Tian S, Kuhlman B, de Silva AM. Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains. J Virol. 2025 May 20;99(5):e0022925. doi: 10.1128/jvi.00229-25. Epub 2025 Apr 16. PMID: 40237498; PMCID: PMC12090738.

Hein LD, Castillo IN, Medina FA, Vila F, Segovia-Chumbez B, Muñoz-Jordán JL, Whitehead SS, Adams LE, Paz-Bailey G, de Silva AM, Premkumar L. Multiplex sample-sparing assay for detecting type-specific antibodies to Zika and dengue viruses: an assay development and validation study. Lancet Microbe. 2025 Feb;6(2):100951. doi: 10.1016/j.lanmic.2024.07.014. Epub 2024 Dec 25. PMID: 39730005; PMCID: PMC12244352.

Agarwal R, Chang J, Côrtes FH, Ha C, Villalpando J, Castillo IN, Gálvez RI, Grifoni A, Sette A, Romero-Vivas CM, Heise MT, Premkumar L, Falconar AK, Weiskopf D. Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans. Cell Rep Med. 2025 May 20;6(5):102134. doi: 10.1016/j.xcrm.2025.102134. PMID: 40398392; PMCID: PMC12147901.

Bos S, Zambrana JV, Duarte E, Graber AL, Huffaker J, Montenegro C, Premkumar L, Gordon A, Kuan G, Balmaseda A, Harris E. Serotype-specific epidemiological patterns of inapparent versus symptomatic primary dengue virus infections: a 17-year cohort study in Nicaragua. Lancet Infect Dis. 2025 Mar;25(3):346-356. doi: 10.1016/S1473-3099(24)00566-8. Epub 2024 Oct 25. PMID: 39489898; PMCID: PMC11864988.

Mielke D, Li SS, Schuster DJ, Li X, Hu J, Karuna S, Seaton KE, Brackett C, Dunn B, Keyes T, Zalaquett A, Stanfield-Oakley S, Zhang L, Wesley MS, Eisel N, Yates NL, Shen X, Premkumar L, Germain RS, Sholukh AM, Cohen K, de Rosa S, Randhawa AK, Hural JA, Corey L, McElrath MJ, Tomaras GD, Hyrien O, Ferrari G. Distinct immune responses in people living with HIV following SARS-CoV-2 recovery. Commun Med (Lond). 2025 Apr 23;5(1):132. doi: 10.1038/s43856-025-00839-1. PMID: 40269243; PMCID: PMC12018938.

Mallory M, Munt JE, Narowski TM, Castillo I, Cuadra E, Pisanic N, Fields P, Powers JM, Dickson A, Harris R, Wargowsky R, Moran S, Allabban A, Raphel K, McCaffrey TA, Brien JD, Heaney CD, Lafleur JE, Baric RS, Premkumar L. COVID-19 point-of-care tests can identify low-antibody individuals: In-depth immunoanalysis of boosting benefits in a healthy cohort. Sci Adv. 2024 Jun 14;10(24):eadi1379. doi: 10.1126/sciadv.adi1379. Epub 2024 Jun 12. PMID: 38865463; PMCID: PMC11168476.
Joseph JO, Ylade M, Daag JV, Aogo R, Crisostomo MV, Mpingabo P, Premkumar L, Deen J, Katzelnick LC. High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines. BMC Infect Dis. 2024 Sep 27;24(1):1042. doi: 10.1186/s12879-024-09672-8. PMID: 39333882; PMCID: PMC11430261.

Adams C, Carbaugh DL, Shu B, Ng TS, Castillo IN, Bhowmik R, Segovia-Chumbez B, Puhl AC, Graham S, Diehl SA, Lazear HM, Lok SM, de Silva AM, Premkumar L. Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus. PLoS Pathog. 2023 Jan 10;19(1):e1010814. doi: 10.1371/journal.ppat.1010814. PMID: 36626401; PMCID: PMC9870165.

Yu ED, Narowski TM, Wang E, Garrigan E, Mateus J, Frazier A, Weiskopf D, Grifoni A, Premkumar L, da Silva Antunes R, Sette A. Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic. Cell Host Microbe. 2022 Sep 14;30(9):1269-1278.e4. doi: 10.1016/j.chom.2022.07.012. Epub 2022 Jul 20. PMID: 35932763; PMCID: PMC9296686.

Narowski TM, Raphel K, Adams LE, Huang J, Vielot NA, Jadi R, de Silva AM, Baric RS, Lafleur JE, Premkumar L. SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people. Cell Rep. 2022 Feb 1;38(5):110336. doi: 10.1016/j.celrep.2022.110336. Epub 2022 Jan 20. PMID: 35090596; PMCID: PMC8769879.

Churiwal M, Lin KD, Khan S, Chhetri S, Muller MS, Tompkins K, Smith J, Litel C, Whittelsey M, Basham C, Rapp T, Cerami C, Premkumar L, Lin JT. Assessment of the Field Utility of a Rapid Point-of-Care Test for SARS-CoV-2 Antibodies in a Household Cohort. Am J Trop Med Hyg. 2021 Nov 24;106(1):156-159. doi: 10.4269/ajtmh.21-0592. PMID: 34818625; PMCID: PMC8733539.

Adams C, Jadi R, Segovia-Chumbez B, Daag J, Ylade M, Medina FA, Sharp TM, Munoz-Jordan JL, Yoon IK, Deen J, Lopez AL, de Silva AM, Premkumar L. Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines. Emerg Infect Dis. 2021 Dec;27(12):3073-3081. doi: 10.3201/eid2712.211150. PMID: 34808091; PMCID: PMC8632176.

Kudlacek ST, Metz S, Thiono D, Payne AM, Phan TTN, Tian S, Forsberg LJ, Maguire J, Seim I, Zhang S, Tripathy A, Harrison J, Nicely NI, Soman S, McCracken MK, Gromowski GD, Jarman RG, Premkumar L, de Silva AM, Kuhlman B. Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies. Sci Adv. 2021 Oct 15;7(42):eabg4084. doi: 10.1126/sciadv.abg4084. Epub 2021 Oct 15. PMID: 34652943; PMCID: PMC8519570.
Katzelnick LC, Narvaez C, Arguello S, Lopez Mercado B, Collado D, Ampie O, Elizondo D, Miranda T, Bustos Carillo F, Mercado JC, Latta K, Schiller A, Segovia-Chumbez B, Ojeda S, Sanchez N, Plazaola M, Coloma J, Halloran ME, Premkumar L, Gordon A, Narvaez F, de Silva AM, Kuan G, Balmaseda A, Harris E. Zika virus infection enhances future risk of severe dengue disease. Science. 2020 Aug 28;369(6507):1123-1128. doi: 10.1126/science.abb6143. PMID: 32855339; PMCID: PMC8274975.

Premkumar L, Segovia-Chumbez B, Jadi R, Martinez DR, Raut R, Markmann A, Cornaby C, Bartelt L, Weiss S, Park Y, Edwards CE, Weimer E, Scherer EM, Rouphael N, Edupuganti S, Weiskopf D, Tse LV, Hou YJ, Margolis D, Sette A, Collins MH, Schmitz J, Baric RS, de Silva AM. The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients. Sci Immunol. 2020 Jun 11;5(48):eabc8413. doi: 10.1126/sciimmunol.abc8413. PMID: 32527802; PMCID: PMC7292505.