Patricia Maness, PhD, Receives NIH R01 Titled, “Mechanisms of Developmental Spine Pruning Regulated by Ig-CAMS and Semaphorins”
August 31, 2017
The focus of this grant is to illuminate a novel mechanism for dendritic spine pruning in the mammalian neocortex by immunoglobulin (Ig)-class cell adhesion molecules and secreted Semaphorins. The overall goal is to identify mechanisms that govern synaptic connectivity in the mammalian neocortex, and to elucidate how their deficiency contributes...