The focus of this grant is to illuminate a novel mechanism for dendritic spine pruning in the mammalian neocortex by immunoglobulin (Ig)-class cell adhesion molecules and secreted Semaphorins. The overall goal is to identify mechanisms that govern synaptic connectivity in the mammalian neocortex, and to elucidate how their deficiency contributes to abnormal brain wiring relevant to neurodevelopmental disorders.

Anne Marion Taylor’s lab receives an American Heart Association grant to further their research investigating how axon damage causes synaptic remodeling following stroke