Jason Stein and Hyejung Won recently published an article in Cell on the dynamic landscape of open chromatin during human neurogenesis.

Anton Lab Researchers pinpoint signaling problems in the progenitor cells crucial for proper neuron generation and organization.

Microcephaly is a hallmark of Angelman syndrome (AS), a debilitating neurodevelopmental disorder that results from loss of function of the HECT domain E3 ubiquitin ligase, UBE3A. However, until recently, the underlying causes of slowed brain growth in individuals with AS had gone unstudied, resulting in significant gaps in understanding of the pathogenesis of the disorder.