Osteoarthritis and Disease Modification: Where are We?
Richard Loeser, MD
April 12, 2023, at 7:00 am
Hybrid Conference
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Speaker Biography
Dr. Loeser’s primary research goal is to discover the basic mechanisms relevant to joint tissue destruction in osteoarthritis. Osteoarthritis (OA) is the leading cause of pain and disability in older adults. A better mechanistic understanding of OA is needed in order to develop interventions that can slow or stop disease progression before advanced joint tissue destruction occurs.
Dr. Loeser’s lab uses a combination of in vitro experiments using human joint tissue cells and in vivo experiments in rodent models to study cell signaling pathways that regulate anabolic and catabolic activity responsible for joint tissue remodeling and destruction. The lab is particularly interested in determining how reactive oxygen species regulate chondrocyte signaling downstream of integrins, cytokines and growth factors through the oxidation of specific cysteine residues in kinases and phosphatases as well as other intracellular proteins. The lab is studying how oxidative stress that occurs with aging and joint injury can alter the activity of these signaling pathways.
Dr. Loeser’s clinical research interest is in exercise and weight loss interventions for knee OA as well as the potential role of gut microbiota in OA. He has been involved in OA biomarker studies that have included metabolomics work and recently in a multidisciplinary effort to define OA phenotypes.
Zoom Details
https://zoom.us/j/95438942692?pwd=SG02REt3UFlZL2NjQmRLVVRhOEZUZz09
Meeting ID: 954 3894 2692
Passcode: 121212
In-Person Location
BioInformatics Room 1131
Accreditation Statement
The School of Medicine of the University of North Carolina at Chapel Hill is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Statement
The School of Medicine of the University of North Carolina at Chapel Hill designates this live activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only those hours of credit actually spent in the educational activity.
Other health professionals will receive a certificate of attendance from an AMA PRA Category 1™ activity. These certificates are accepted by the NC Boards for physician assistants, nurse practitioners, nurses, and respiratory therapists. Other health care providers may also be able to use these certificates, depending on their particular license requirements. (License requirements are subject to change. Participants should check with their licensing boards for specific questions. UNC and its partners are not responsible for changes in license requirements.)
Disclosure statement
This activity has been planned and implemented under the sole supervision of the course director and planning committee, in association with the UNC Office of Continuing Professional Development (UNC CPD). The course director, planning committee, presenters, and CPD staff have no relevant financial relationships with commercial interests as defined by the ACCME.
Credit Limitation
Credit is only available to employees of UNC or its affiliates. To claim credit please contact the Grand Rounds Coordinator.
Grand Rounds Coordinator
Chi-Chi Harris
Email: chania_harris@med.unc.edu