Researchers clarify role of mutations in glioblastoma

July 10, 2018

In a preclinical study, researchers led by UNC Lineberger’s Ryan Miller, MD, investigated whether the location of where the mutation occurred within the sequence of the PIK3CA gene affected the mutation’s ability to help drive cancerous growth. They also evaluated whether the location of the mutation would affect the cancer’s response to certain treatments. Read … Continued

Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy

May 2, 2017

In a pair of preclinical studies published in the journal Neuro-Oncology, researchers from UNC Lineberger and the Phoenix-based Translational Genomics Research Institute report on the genetic evolution of glioblastoma as it progresses in severity and a potential strategy to treat this often fast-growing brain cancer type. Read more about this important discovery in at the UNC Lineberger Comprehensive … Continued

New Glioblastoma Treatment Successfully Tested with Human Cells

February 1, 2017

A new study published today in Science Translational Medicine from the team of Shawn Hingtgen, Ryan Miller, and Matt Ewend at the UNC Eshelman School of Pharmacy and School of Medicine shows that human skin cells converted to neural stem cells deliver therapeutics that inhibit progression of the deadliest adult brain tumor, glioblastoma.    Read … Continued

Robert McNeill featured in American Society for Investigative Pathology (ASIP) Trainee Newsletter

February 1, 2017

https://www.asip.org/Trainee_Newsletter/Oct2016/press.cfm BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea-Induced Gliomagenesis [Commentary] Robert S. McNeill, David M. Irvin, and C. Ryan Miller Am J Pathol 2016, 189:2551-2554 Commentary, published October 2016 in the American Journal of Pathology, written on Short Communication: Wang Q, Satomi K, Oh JE, Hutter B, Brors B, Diessl N, Liu H-K, Wolf S, Otmar … Continued

Yang, Miller receive UNC TraCS award

August 31, 2016

The NC TraCS Institute is pleased to announce awardees in the 14th cycle of the TraCS $5K-$50K grants for clinical and translational research projects. Yang Yang, PhD C. Ryan Miller, MD, PhD Project Title:  Validating Trans-Lesion Synthesis as a Novel Therapeutic Target in Glioblastoma