The 2025 MPS MasterClass brought together clinicians, researchers, families, and advocates for two days of focused education and collaboration, drawing more than 360 total views across its live Zoom sessions. Hosted by the Muenzer MPS Research & Treatment Center, the virtual program featured expert-led presentations on diagnosis, treatment advancements, clinical management, and emerging therapies across the spectrum of Mucopolysaccharidoses. Attendees from around the world engaged in sessions designed to strengthen clinical knowledge, support care teams, and empower the MPS community. With strong participation and positive feedback, the MasterClass underscored the continued need for accessible, high-quality education in rare disease care and research.