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Shown are schematics of three core projects of the Pruitt lab.

Project 1

We are defining the role of DVL paralogs in mediating oncogenic signaling
and regulating immune evasion in the tumor microenvironment.

Project 2

We are defining the role that estrogen synthesis and signaling play in regulating
malignant properties of cancers such as colorectal cancer.

Project 3

We are elucidating the role of epigenetic regulators such as DNA methylation readers and histone
modifying enzymes in mediating oncogenic signaling in breast and colorectal cancer.