Dishevelled (DVL)

1. DVL is associated with multiple cancers
2. DVL’s role in regulating immune evasion
3. DVL’s associated transcription.
Center diagram shows DVL’s regulation of Wnt signaling.

Questions the Pruitt lab seeks to address

What regulates DVL nuclear translocation?
What are the transcription factors associated with nuclear DVL?
What is the functional significance of DVL post translational modifications?
What is the association between DVL and the tumor immune microenvironment?