We offer an array of sample preparation and instrumentation services, as well as method development and in-depth consultation to help researchers optimize their experimental design based on their experimental goals. Recognized as a Thermo Fisher Scientific Center of Excellence, our facility is equipped with seven state-of-the-art mass spectrometry systems: Thermo Orbitrap Astral, Exploris480 (2), QExactive HF, Fusion Lumos, Exploris240 and Stellar. In addition to the mass spectrometers, we have a Thermo Ultimate3000, three Thermo Easy nLC 1200s, an Evosep One, two Vanquish Neo UHPLCs, three Vanquish Horizon UHPLCs, and two 908 Devices ZipChip capillary electrophoresis devices for up-front separation. We have an Agilent 1260 Infinity II HPLC for offline peptide fractionation. We are also equipped with a Thermo AccelerOme for automated high-throughput sample preparation, and a Seer Proteograph for enrichment of low-abundance proteins from plasma and other biofluids.

We offer several proteomics services including: protein identification, protein characterization, post-translational modification (PTM) mapping / profiling (for example: phosphoproteomics, acetylomics), large-scale proteomic profiling, chemoproteomics, intact mass analysis, and affinity purification analyses. We can perform these services quantitatively using labeled (TMT10plex/16plex/18plex) or label-free approaches (DDA or DIA). Comprehensive data analysis is provided through a variety of database search engines and software packages including Proteome Discoverer, MaxQuant, Spectronaut, and Skyline. We can also aid in bioinformatics analysis using Ingenuity Pathway Analysis (IPA), Gene Ontology, Perseus, and R.

Research at the MAP Core is supported by funding from the UNC Nutrition and Obesity Center (NORC) and the Lineberger Comprehensive Cancer Center (LCCC). 

We host a monthly Mass Spectrometry Seminar Series to highlight exciting research at UNC and promote collaborative opportunities. MS Seminars and other events are posted on our Events page. If you’d like to receive updates and join our mailing list, please complete the short form linked below.

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