Characterizing the spectrum of distress symptoms in midlife women with perimenopausal depression
March 18, 2026
This study compared late-perimenopausal women with and without perimenopausal-onset major depressive disorder (PO-MDD) to examine patterns of depression, anxiety, temperament, and menopausal symptoms. Women with PO-MDD showed significantly higher levels of irritability, anxiety, negative temperament, and overall menopausal distress, suggesting that screening for anxiety and related symptoms is important when...