Category: Research Publications

We investigated how different breathing techniques impact electrical activity in the brain.

Research led by Dr. Robert Mealer describes how a unique class of sugar molecules in the brain is enriched a specialized structures called nodes of Ranvier. This work provides new insight to a group of genes that are involved with genetic disorders of the brain, including schizophrenia.

This paper describes the learning health system model used to create Connection Learning Healthcare System (CLHS): a network of academic institutions, state behavioral health systems, and early psychosis specialty care programs in Pennsylvania and Maryland. It reviews lessons learned and areas of ongoing attention.

This was the first study to examine white matter microstructure in school-aged children with Down Syndrome. A spatially specific pattern of results indicated a dissociation between intra- and inter-hemispheric pathways, which could inform more targeted interventions and clinical trials in Down Syndrome.

This research describes how a unique class of sugar molecules in the brain is enriched a specialized structures called nodes of Ranvier. This work provides new insight to a group of genes that are involved with genetic disorders of the brain, including schizophrenia.

This paper describes the learning health system model used to create Connection Learning Healthcare System (CLHS): a network of academic institutions, state behavioral health systems, and early psychosis specialty care programs in Pennsylvania and Maryland. It reviews lessons learned and areas of ongoing attention.

Estrogen treatment during menopause increased right hippocampal volumes in women without depression. In women with depression, decreases in right hippocampal volumes predicted decreases in mood symptoms following estrogen treatment.

We investigated how different breathing techniques impact electrical activity in the brain.

Adolescence is a critical period of developmental changes in neurobiological and psychological systems, rendring it both a period of vulnerability for the emergence of risk factors associated with psychopathology and a period of opportunity for the implementation of targeted prevention and interventions. Anhedonia (i.e., the reduced ability to anticipate or...

Background: Neuroimmune dysfunction in alcohol use disorder (AUD) is associated with activation of myeloid differentiation primary response 88 (MyD88)-dependent Toll-like receptors (TLR) resulting in overexpression of the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). MCP-1 overexpression in the brain is linked to anxiety, higher alcohol intake, neuronal death, and activation of microglia...