Category: Research Publications

This work examines whether there are changes in the self-report of anxiety and depression symptoms in adults with cystic fibrosis (CF) who started taking elexacaftor/tezacaftor/ivacaftor (E/T/I), a new medication that shows great promise in the treatment of CF. The study found that there were no changes in these symptoms in...

Research on resilience after trauma has often focused on individual-level factors (e.g., extensive trauma history) and overlooked influential neighborhood-level factors that may help mitigate the development of posttraumatic stress disorder (PTSD). We applied geospatial analyses to the AURORA Study dataset and evaluated whether greenspace was associated with PTSD trajectories. We...

A deep learning AI model was developed to estimate gestational age (GA) from blind ultrasonography sweeps and incorporated into a low-cost, battery-powered device, aiming to improve pregnancy care in low-resource settings. The study found that novice users, with no prior sonography training, could estimate GA with the AI tool as...

Determining the causes of schizophrenia has been a notoriously intractable problem, resistant to a multitude of investigative approaches over centuries. In recent decades, genomic studies have delivered hundreds of robust findings that implicate nearly 300 common genetic variants (via genome-wide association studies) and more than 20 rare variants (via whole-exome...

This is review, led by Dr. Nakamura and in collaboration with an international working group, is the most comprehensive review to date of cognitive rehabilitation interventions to improve cognitive difficulties and daily function in patients with cancer.

This Open Forum argues that marginalization and disparities in early psychosis research and clinical care are interrelated, and the authors provide suggestions for paths forward. Commitment to equity and justice demands recentering the perspectives of those most affected by early psychosis services and investing in the integration of historically excluded...

Analyzing 1787 discharges from the Early Psychosis Intervention Network (EPINET), a NIMH national network of >100 Coordinated Specialty Care programs for individuals with early psychosis, we estimated that only 20-30% of participants completed early psychosis programing. Completion rate is positively associated with age on admission, time in education, employment, or...

This study probed the neurocardiac circuit by examining associations among its core regions in the brain (e.g., hypothalamus) and the periphery (heart rate [HR], high frequency heart rate variability [HF-HRV], and blood pressure [BP]). Participants were 315 trauma-exposed adults enrolled from emergency departments as part of the prospective AURORA study....

Utilizing national longitudinal data, this study examined how polygenic depression risk and childhood abuse interactively influence the life-course development of depressive conditions from middle to late adulthood. The results revealed that Increasing polygenic depression scores were associated with elevated CES-D levels and potential risks of clinical depression. Non-maltreated females generally...

Increased sensitivity to ovarian hormone changes is implicated in the etiology of reproductive mood disorders across the female lifespan, including menstrually-related mood disorders, perinatal mood disorders, and perimenopausal depression. We developed a novel method to accurately quantify sensitivity to endogenous hormone fluctuations that may facilitate the prediction and prevention of...