Category: Research Publications

This commentary delves into a survey of 200 American Psychiatrists that examines their responses on treating individuals with treatment-resistant psychiatric conditions. The commentary highlights how varying viewpoints on the concept of treatment futility shape the interpretation of the survey findings.

This study tested the effect of twice-daily intranasal oxytocin on cognitive outcomes in individuals with schizophrenia and schizoaffective disorder. We observed that intranasal oxytocin did not significantly improve cognition in individuals with schizophrenia compared to placebo.

Huang et al. demonstrate that visual thalamic theta oscillations causally coordinate the posterior visual network to enhance sustained attention. This coordination is frequency and state dependent.

Adopting a framework of equity is urgently needed to reduce disparities persistent in feeding and eating disorder (FED) treatment models. This framework must emphasize the exchange of knowledge between relevant stakeholders and implementation strategies to impact practice and embrace a systemic change in the FED field.

The results demonstrate neurosteroid allopregnanolone enhancement of the endosomal TLR4-TRIF anti-inflammatory signals and elevations of IL-10 in male P rat brain that were not detected in female P rat brain. These anti-inflammatory signals are neuroprotective and counter inflammatory signals that are common in alcohol use disorders and depression. The data...

An examination of 20 years of clinical data indicate that diagnosis of autism in females has increased over the years, likely reflecting greater knowledge of how autism presents in females.

In this study, enlarged perivascular spaces at 24 months of age were associated with autism diagnosis, excessive cerebrospinal fluid volume, and later sleep problems. Findings suggest the glymphatic system may be dysregulated in infants who develop autism.

Age-related decline is observed across multiple neurocognitive domains. Normative cognitive aging may be accelerated by a history of early life adversity and psychiatric disorders. The present results provide evidence that epigenetic age acceleration have the potential to serve as a biomarker for cognitive decline in patients with a child maltreatment...

Following trauma, individuals often face significant neuropsychiatric challenges, known as adverse post-traumatic neuropsychiatric sequelae (APNS). Although the biological factors behind APNS remain unclear, this study explored the role of the microbiota-gut-brain axis in understanding and influencing components of APNS. By analyzing stool samples from trauma-exposed emergency department patients, we identified...